Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed. Some authors suggested
a relationship between more severe infections and NSAIDs exposure, especially skin
and soft tissue infections (SSTI). However, their impact during bacterial infections
remains unclear. The aim of the study was to report the severity features of patients
having bacterial infection who were exposed to NSAIDs prior to their hospitalisation.
Cases of infected patients with these characteristics declared to the pharmacovigilance
department of a French university hospital from 1 January 2011 to 31 December 2013
were retrospectively reviewed.
Forty-one patients were included, mainly male (61%). Median age was 37 years. No underlying disease was noted for 68% of cases. Ibuprofen was the most frequent
drug (63%). Self-medication concerned 61% of cases. Respiratory tract, osteoarticular
and SSTI were the most frequent infected sites. Patients suffered septic complications:
dissemination of infection to more than one site (51%), suppuration (59%), and requirement
for invasive procedures (32%). Eleven patients (27%) had severity criteria as usually
defined (10 severe sepsis and 1 septic shock) and 30 did not. There was no significant
difference regarding the rate of septic complications between the severe and non-severe
group.
Septic complications frequently occurred in patients with NSAIDs exposure, whether
or not there was severe sepsis or shock. Further studies investigating the impact
of NSAIDs in bacterial infections should consider the septic complications depicted
here as clinically relevant endpoints. Moreover, clinicians should seek those complications
in case of bacterial infections and NSAIDs use.
Keywords
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Article info
Publication history
Published online: March 13, 2017
Accepted:
March 3,
2017
Received in revised form:
February 28,
2017
Received:
February 16,
2017
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
