We read with great interest the recently published article by Zachou et al., in which
they investigated the possible application of serum cartilage oligomeric matrix protein
(COMP) levels as a novel non-invasive marker of fibrosis in patients with chronic
viral hepatitis (CVH) and compared this marker with histology, transient elastography
(TE), APRI and FIB-4 for the estimation of fibrosis stage [
[1]
]. They concluded that serum COMP levels performed as well as TE, APRI and FIB-4 score
in detecting cirrhosis in CVH patients [
[1]
]. It is a nice work. However, we are concerned about several points in this article.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- COMP serum levels: a new non-invasive biomarker of liver fibrosis in patients with chronic viral hepatitis.Eur J Intern Med. 2017; 38: 83-88https://doi.org/10.1016/j.ejim.2017.01.007
- Cartilage oligomeric matrix protein expression in hepatocellular carcinoma and the cirrhotic liver.J Gastroenterol Hepatol. 2004; 19: 296-302
Norman GL, Gatselis NK, Shums Z, et al. Cartilage oligomeric matrix protein: a novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma. World J Hepatol 2015;7:1875–83. http://dx.doi.org/10.4254/wjh.v7.i14.1875.
- Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.Hepatol Int. 2016; 10: 1-98https://doi.org/10.1007/s12072-015-9675-4
Shiha G, Ibrahim A, Helmy A, et al. Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update. Hepatol Int 2017;11(1):1–30. doi: 10.1007/s12072-016-9760-3.
- Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection.World Health Organization, Geneva2015
Article info
Publication history
Published online: April 18, 2017
Accepted:
April 13,
2017
Received in revised form:
April 12,
2017
Received:
April 7,
2017
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
