Highlights
- •The risk of cancer in patients with primary hyperparathyroidism (1HPT) is discussed.
- •The cancer risk was evaluated in 163 patients with 1HPT and in 1443 controls.
- •During the 10 years before the study, the cancer risk was increased in 1HPT patients
- •Breast, kidney and skin cancer were the more frequent malignancies in 1HPT patients
- •The 1HPT diagnosis was associated with these cancers regardless for confounders.
Abstract
Introduction
The association between primary hyperparathyroidism (1HPT) and cancer is debated.
The present study was aimed to investigate the occurrence of neoplasia in 1HPT.
Patients and methods
All consecutive patients (n = 1750) referred to our “Osteoporosis and Metabolic Disease” outpatients clinic for
osteoporosis or hypercalcemia were eligible for the study. The exclusion criteria
were: the finding of osteoporosis and/or altered calcium-phosphorous metabolism in
the context of investigations for malignancy, the presence of diseases known to influence
the cancer risk and the heavy smoking habit. Eventually, 1606 patients (1407 females,
199 males) were enrolled. In all patients calcium-phosphorous metabolism, PTH and
vitamin D levels were measured and the occurrence of cancer during the 10 years prior the study inclusion was recorded.
Results
One-hundred-sixty-three patients had 1HPT while 1443 had not. Patients with and without
1HPT were comparable for age and gender. In 1HPT patients the occurrence of all, breast,
kidney and skin cancer was significantly higher (21.5%, 12.2%, 2.5%, 1.8%, respectively)
than in patients without 1HPT (12.4%, 6.9%, 0.3%, 0.3%, p < 0.05 for all comparisons). The 1HPT presence was significantly associated with the
occurrence of all neoplasia and of breast, skin and kidney neoplasia (odds ratio,
95% confidence interval, p value: 1.93, 1.27–2.92, 0.002; 1.93, 1.11–3.35, 0.002;
9.18, 2.16–38.8, 0.003; 8.23, 1.71–39.5, 0.008, respectively), after adjusting for
age, gender (as appropriate), smoking habit and vitamin D levels.
Conclusion
During the 10 years prior the diagnosis of 1HPT, the occurrence of all, breast, skin and kidney
neoplasia is increased.
Keywords
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Article info
Publication history
Published online: June 05, 2017
Accepted:
June 1,
2017
Received in revised form:
May 12,
2017
Received:
March 8,
2017
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
