Disappointingly most clinical research is wasteful as it is either futile or risky for patients [
]. Often its questions pursue aims other than the unmet clinical needs they claim to address, and their methods cannot provide patients with useful and reliable answers. Limitations include the use of inappropriate controls or no controls at all, the abuse of placebo when effective treatments are available, the adoption of surrogate outcomes that mean little if anything to patients, and the inclusion of too few patients to see an effect that is not due to chance. Then there is always the fact that the investigators cannot independently collect, analyse and publish their own data in sponsor-driven studies [
- Chalmers I.
- Glasziou P.
Avoidable waste in the production and reporting of research evidence.
Lancet. 2009; 374: 86-89https://doi.org/10.1016/S0140-6736(09)60329-9
]. Even so, the scientific community still hosts the findings of these studies in its journals and regulatory authorities rely on them to allow new products onto the market.
- Garattini S.
- Jakobsen J.C.
- Wetterslev J.
- Bertelè V.
- Banzi R.
- Rath A.
- et al.
Evidence-based clinical practice: overview of threats to the validity of evidence and how to minimise them.
Eur J Intern Med. 2016; 32 ([Review]): 13-21https://doi.org/10.1016/j.ejim.2016.03.020
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to European Journal of Internal Medicine
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Avoidable waste in the production and reporting of research evidence.Lancet. 2009; 374: 86-89https://doi.org/10.1016/S0140-6736(09)60329-9
- Evidence-based clinical practice: overview of threats to the validity of evidence and how to minimise them.Eur J Intern Med. 2016; 32 ([Review]): 13-21https://doi.org/10.1016/j.ejim.2016.03.020
- Models and applications for measuring the impact of health research: update of a systematic review for the Health Technology Assessment Programme.Health Technol Assess. 2016; 20https://doi.org/10.3310/hta20760
Published online: June 17, 2017
Accepted: June 12, 2017
Received: June 6, 2017
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.