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Effect of pregnancy in women with a history of primary immune thrombocytopenia considered as cured

Published:August 26, 2017DOI:https://doi.org/10.1016/j.ejim.2017.08.023
      Immune thrombocytopenia (ITP) is the most common autoimmune cytopenia. This disease often occurs in young women [
      • Moulis G.
      • Palmaro A.
      • Montastruc J.-L.
      • Godeau B.
      • Lapeyre-Mestre M.
      • Sailler L.
      Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France.
      ]. Pregnancy is a well-known risk factor for developing newly diagnosed ITP as well as for inducing disease flares in patients with chronic ITP [
      • Kelton J.G.
      Idiopathic thrombocytopenic purpura complicating pregnancy.
      ]. Severe bleeding is rare but a therapeutic intervention is needed for one third of the pregnant patients, mostly before delivery to allow peridural analgesia [
      • Loustau V.
      • Debouverie O.
      • Canoui-Poitrine F.
      • Baili L.
      • Khellaf M.
      • Touboul C.
      • et al.
      Effect of pregnancy on the course of immune thrombocytopenia: a retrospective study of 118 pregnancies in 82 women.
      ,
      • Webert K.E.
      • Mittal R.
      • Sigouin C.
      • Heddle N.M.
      • Kelton J.G.
      A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura.
      ]. However, the impact of pregnancy in women with an old history of ITP, considered as cured, has not been assessed. The aim of this study was to describe the course of ITP in pregnant women with an ITP in complete remission (platelet count > 100 × 109/L and absence of bleeding symptoms) for at least 5 years without any ITP treatment.

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