Highlights
- •In patients with advanced heart failure and palliative home care 54% had anaemia.
- •In these patients 47% also hade iron deficiency (ID).
- •Anaemia was associated with symptoms, quality of life and health-related questions.
- •ID was not associated with symptoms, quality of life and health-related questions.
Abstract
Background
To explore the relationships between anaemia or iron deficiency (ID) and symptoms,
quality of life (QoL), morbidity, and mortality.
Methods
A post-hoc, non-prespecified, explorative substudy of the prospective randomized PREFER
trial. One centre study of outpatients with severe HF and palliative need managed
with advanced home care. Associations between anaemia, ID, and the Edmonton Symptom
Assessment Scale (ESAS), Euro QoL (EQ-5D), Kansas City Cardiomyopathy Questions (KCCQ)
were examined only at baseline but at 6 months for morbidity and mortality.
Results
Seventy-two patients (51 males, 21 females), aged 79.2 ± 9.1 years. Thirty-nine patients (54%) had anaemia and 34 had ID (47%). Anaemia was correlated
to depression (r = 0.37; p = 0.001), anxiety (r = 0.25; p = 0.04), and reduced well-being (r = 0.26; p = 0.03) in the ESAS; mobility (r = 0.33; p = 0.005), pain/discomfort (r = 0.27; p = 0.02), and visual analogue scale of health state (r = −0.28; p = 0.02) in the EQ-5D; and physical limitation (r = −0.27; p = 0.02), symptom stability; (r = −0.43; p < 0.001); (r = −0.25; p = 0.033), social limitation;(r = −0.26; p = 0.03), overall summary score; (r = −0.24, p = 0.046) and clinical summary score; (r = −0.27; p = 0.02) in the KCCQ. ID did not correlate to any assessment item. Anaemia was univariably
associated with any hospitalization (OR: 3.0; CI: 1.05–8.50, p = 0.04), but not to mortality. ID was not significantly associated with any hospitalization
or mortality.
Conclusion
Anaemia, but not ID, was associated although weakly with symptoms and QoL in patients
with advanced HF and palliative home care.
Keywords
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Article info
Publication history
Published online: September 09, 2017
Accepted:
August 30,
2017
Received in revised form:
August 23,
2017
Received:
February 14,
2017
Identification
Copyright
© 2017 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.
