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The effects of protein intake on albuminuria in different estimated glomerular filtration rate: A population-based study

  • Yan Liu
    Correspondence
    Corresponding author at: Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China.
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China

    Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Rong-shao Tan
    Affiliations
    Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Dao-yuan Zhou
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China

    Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
    Search for articles by this author
  • Xiao Xiao
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Jian-min Ran
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China

    Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Dan-ping Qin
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Xiao-shi Zhong
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Jian-guang Hu
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Yun Liu
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China

    Guangzhou Institute of Disease-Oriented Nutritional Research, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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  • Yuan-yuan Zheng
    Affiliations
    Department of Nephrology, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Medical College of Jinan University, No. 396 Tong Fu Zhong Road, Guangzhou 510220, China
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Published:November 06, 2017DOI:https://doi.org/10.1016/j.ejim.2017.10.022

      Highlights

      • Albuminuria in stage 1 chronic kidney disease (CKD) is associated with activity level.
      • Albuminuria in stage 1 CKD is associated with blood glucose level.
      • Albuminuria is associated with protein intake in those 45–65 years with stage 1 CKD.
      • Diabetes is associated with albuminuria in those ≥65 years with stage 2 and 3 CKD.
      • These data support the importance of lifestyle changes in the management of CKD.

      Abstract

      Background

      Chronic kidney disease (CKD) is a serious condition associated with early mortality, decreased quality of life, and increased health-care expenditures.

      Methods

      Data from the National Health and Nutrition Examination Survey (NHANES) collected from 1999 to 2012 were used. Subjects were divided into 4 estimated glomerular filtration rate (eGFR) categories: stage 1: eGFR ≥ 90 mL/min/1.73 m2, stage 2: eGFR 60–89, stage 3: eGFR 30–59, and stage 4/5: eGFR < 30, and 3 age strata (<45y, 45–64, 65+). Associations between protein intake and albuminuria were determined.

      Results

      A total of 45,259 subjects were included. Despite decreasing protein intake, there was a significant increase in the prevalence of albuminuria with decreasing levels of eGFR. Multivariable analysis showed that albuminuria was associated with daily protein intake in patients ≥65 years old with stage 1 disease, and that diabetes was associated with albuminuria in patients ≥65 years old with stage 2 and 3 diseases. Overall, albuminuria in patients with stage 1 disease was associated with hours of sitting per day and blood glucose level.

      Conclusion

      Albuminuria was associated with daily protein intake in patients of 45–64 years old with stage 1 CKD disease, and was associated with hours of sitting per day and blood glucose level. These data further support the importance of lifestyle changes in the management of CKD, especially in patients with early-stage disease.

      Keywords

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