Highlights
- •Cardiovascular events (CVE) appear in 2.8% of liver transplant (LT) recipients.
- •Coronary heart disease exists in 6.8% of LT recipients pretransplant.
- •CVE are more frequent in patients with preexisting coronary heart disease.
Abstract
Background
Cardiovascular disease is a serious problem of liver transplant (LT) recipients because
of increased cardiovascular risk due to immunosuppressive therapy, higher age, intraoperative
risk and comorbidities (such as diabetes and nicotine abuse). Reported frequency of
cardiovascular events after LT shows a high variability between different LT cohorts.
Our aim was to analyze a cohort of LT recipients from a single center in Germany to
evaluate frequency of the cardiovascular endpoints (CVE) myocardial infarction and/or
cardiac death after LT and to investigate correlations of CVE post LT with pretransplant
patient characteristics.
Patients
In total, data from 352 LT patients were analyzed. Patients were identified from an
administrative transplant database, and all data were retrieved from patients' charts
and reports.
Results
During the median follow-up of 4.0 (0−13) years, 10 cases of CVE were documented (six myocardial infarctions and four coronary
deaths). The frequency of CVE did not differ according to classic cardiovascular risk
factors such as body mass index (p = 0.071), total cholesterol (p = 0.533), hypertension (p = 0.747), smoking (p = 1.000) and pretransplant diabetes mellitus (p = 0.146). In patients with pretransplant coronary heart disease (n = 24; 6.8%) CVE were found more frequently (p = 0.024).
Conclusion
In summary, we found a rate of 2.8% CVE after LT in a German transplant cohort. Pretransplant
CHD was the only risk factor for CVE, but showed no significant impact on overall
survival.
Keywords
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Article info
Publication history
Published online: December 08, 2017
Accepted:
December 5,
2017
Received in revised form:
November 20,
2017
Received:
March 12,
2017
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
