Letter to the Editor| Volume 51, e14-e15, May 2018

Significance of macro creatine kinase in admitted patients

Published:February 15, 2018DOI:
      High molecular mass forms have been reported for many serum enzymes measured in clinical laboratories. They are described as either type-1 (a normal enzyme complexed with an immunoglobulin by an antigen-antibody reaction) or type-2 macroenzymes (all other). They are detected in patients examined for persistently increased levels using electrophoretic, chromatographic or immunoinhibition methods, but are indistinguishable from normal enzymes in routine quantitative assays [
      • Galasso P.J.
      • Litin S.C.
      • O'Brien J.F.
      The macroenzymes: a clinical review.


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