High molecular mass forms have been reported for many serum enzymes measured in clinical laboratories. They are described as either type-1 (a normal enzyme complexed with an immunoglobulin by an antigen-antibody reaction) or type-2 macroenzymes (all other). They are detected in patients examined for persistently increased levels using electrophoretic, chromatographic or immunoinhibition methods, but are indistinguishable from normal enzymes in routine quantitative assays [
- Galasso P.J.
- Litin S.C.
- O'Brien J.F.
The macroenzymes: a clinical review.
Mayo Clin. Proc. 1993; 68: 349-354
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- The macroenzymes: a clinical review.Mayo Clin. Proc. 1993; 68: 349-354
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Published online: February 15, 2018
Accepted: February 5, 2018
Received: February 2, 2018
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.