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Association between blood eosinophil count with asthma hospital readmissions

Published:March 04, 2018DOI:https://doi.org/10.1016/j.ejim.2018.02.034

      Highlights

      • The blood eosinophil count (BEC) could have some impact on asthma.
      • The relationship between BEC and asthma prognosis is still under debate.
      • The effect doesn't seem to be the same in all populations.
      • In our population less BEC is related to more exacerbations.

      Abstract

      Introduction

      The presence of eosinophils in asthma inflammation is a relevant factor in the pathophysiology of the disease, however the relationship between the blood eosinophil count (BEC) with asthma severity and prognosis is still under debate.
      The aim of this work is to analyze the relationship between the BEC levels and hospital readmissions in patients with asthma.

      Material and methods

      A review was retrospectively carried out on all admissions of patients over 18 years old due to exacerbation of asthma occurring in our hospital between the years 2000 and 2010. The personal characteristics and the asthma personal history of each patient were recorded. The BEC was determined from the first blood sample taken from the patient after their arrival at the hospital. Hospital early, late and frequent readmissions were analyzed using 4 cut-off points; less than 150 eosinophils/μL vs ≥150/μL, less than 200 vs 200 /μL, less than 300 vs ≥300/μL, and less than 400 vs ≥400/μL.

      Results

      We have included 1316 patients, 70% of whom are women, as well as a mean age of 60 years, and a mean FEV1 of 73.5% of the reference value. The mean eosinophil blood count was 201.7 cells/μL. A BEC ≥300 cells/μL showed a reduction of risk of late readmission of 42%, a BEC ≥400 cells/μL showed a reduction in late readmission risk of 41% and decrease in frequent late readmission of 63%.

      Conclusions

      Our study appears to support that an elevated BEC is associated with a lower incidence of asthma hospital readmissions.

      Graphical abstract

      Keywords

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