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Autonomic dysfunction and cardiovascular risk in patients with atherosclerotic renal artery stenosis: A pilot study

Published:March 07, 2018DOI:https://doi.org/10.1016/j.ejim.2018.03.002
      Atherosclerotic renal artery stenosis (ARAS) is a secondary cause of hypertension, with prevalence ranging from 1% to 5% in hypertensive patients. ARAS is associated with ischemic nephropathy, congestive heart failure and accelerated cardiovascular disease [
      • Cianci R.
      • Martina P.
      • Borghesi F.
      • di Donato D.
      • Polidori L.
      • Lai S.
      • et al.
      Revascularization versus medical therapy for renal artery stenosis: antihypertensive drugs and renal outcome.
      ]. Autonomic dysfunction is a renowned risk factor for cardiovascular disease and several studies have documented that inflammation could play a crucial role between autonomic system and atherosclerosis [
      • Ulleryd M.A.
      • Prahl U.
      • Börsbo J.
      • Schmidt C.
      • Nilsson S.
      • Bergström G.
      • et al.
      The association between autonomic dysfunction, inflammation and atherosclerosis in men under investigation for carotid plaques.
      ]. The aim of the study is to evaluate if markers of increased cardiovascular risk, as autonomic dysfunction and QTc interval prolongation, can be detected in ARAS patients.
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