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Heterogeneity among splanchnic vein thrombosis associated with myeloproliferative neoplasms

Published:March 20, 2018DOI:https://doi.org/10.1016/j.ejim.2018.03.009
      In BCR-ABL1-negative myeloproliferative neoplasms (MPNs) thrombo-hemorrhagic complications represent the most common cause of morbidity and mortality. In particular, the reported overall incidence of major thrombotic events ranges from 1.75 to 5.5% events patient-years according to the specific MPN subtype [
      • Barbui T.
      • Finazzi G.
      • Falanga A.
      Myeloproliferative neoplasms and thrombosis.
      ]. Arterial thrombotic events, including ischemic stroke, acute coronary syndrome and peripheral arterial thrombosis, account for the majority of these complications (60–70%); accidents in the venous compartment, i.e. deep vein thrombosis, pulmonary embolism, and superficial vein thrombosis, account instead for the remaining 30–40% of the cases. Venous thrombosis can occur not only at common sites, but also at unusual sites, including the cerebral or splanchnic circulation (SVT), the latter with a prevalence ranging between 1 and 23%. A recent meta-analysis has confirmed that BCR-ABL1-negative MPNs can be identified in 30–50% of Budd-Chiari syndrome patients, and in 15–30% of those with portal vein thrombosis, representing the leading cause of SVT [
      • Smalberg J.H.
      • Arends L.R.
      • Valla D.C.
      • et al.
      Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis.
      ].

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      References

        • Barbui T.
        • Finazzi G.
        • Falanga A.
        Myeloproliferative neoplasms and thrombosis.
        Blood. 2013; 122: 2176-2184
        • Smalberg J.H.
        • Arends L.R.
        • Valla D.C.
        • et al.
        Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis.
        Blood. 2012; 120: 4921-4928
        • Lavu S.
        • Szuber N.
        • Mudireddy M.
        • et al.
        Splanchnic vein thrombosis in patients with myeloproliferative neoplasms: the Mayo clinic experience with 84 consecutive cases.
        Am. J. Hematol. 2018; 93: E61-E64
        • Gianelli U.
        • Cattaneo D.
        • Bossi A.
        • et al.
        The myeloproliferative neoplasms, unclassifiable: clinical and pathological considerations.
        Mod. Pathol. 2017; 30: 169-179
        • Iurlo A.
        • Cattaneo D.
        • Gianelli U.
        • et al.
        Molecular analyses in the diagnosis of myeloproliferative neoplasm-related splanchnic vein thrombosis.
        Ann. Hematol. 2015; 94: 881-882
        • Gianelli U.
        • Iurlo A.
        • Cattaneo D.
        • et al.
        Discrepancies between bone marrow histopathology and clinical phenotype in BCR-ABL1-negative myeloproliferative neoplasms associated with splanchnic vein thrombosis.
        Leuk. Res. 2015; 39: 525-529
        • Barosi G.
        • Vannucchi A.M.
        • De Stefano V.
        • et al.
        Identifying and addressing unmet clinical needs in Ph-neg classical myeloproliferative neoplasms: a consensus-based SIE, SIES, GITMO position paper.
        Leuk. Res. 2014; 38: 155-160
        • De Stefano V.
        • Qi X.
        • Betti S.
        • Rossi E.
        Splanchnic vein thrombosis and myeloproliferative neoplasms: molecular-driven diagnosis and long-term treatment.
        Thromb. Haemost. 2016; 115: 240-249
        • De Stefano V.
        • Vannucchi A.M.
        • Ruggeri M.
        • et al.
        Splanchnic vein thrombosis in myeloproliferative neoplasms: risk factors for recurrences in a cohort of 181 patients.
        Blood Cancer J. 2016; 6e493