Advertisement

Use of oral anticoagulant drugs in older patients with atrial fibrillation in internal medicine wards

  • Marco Proietti
    Affiliations
    Department of Neuroscience, Laboratory of Quality Assessment of Geriatric Therapies and Services, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy

    Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom
    Search for articles by this author
  • Stefania Antoniazzi
    Affiliations
    Scientific Direction, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

    Department of Biomedical and Clinical Sciences, Clinical Pharmacology Unit, ASST Fatebenefratelli – Sacco University Hospital, University of Milan, Milan, Italy
    Search for articles by this author
  • Valter Monzani
    Affiliations
    Department of Emergency Medicine, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Search for articles by this author
  • Paola Santalucia
    Affiliations
    Scientific Direction, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

    IRCCS Centro Neurolesi Bonino Pulejo - Ospedale Piemonte, Messina, Italy
    Search for articles by this author
  • Carlotta Franchi
    Correspondence
    Corresponding author at: Unit of Pharmacoepidemiological Research in Older People, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Via Giuseppe La Masa 19, 20156 Milan, Italy.
    Affiliations
    Unit of Pharmacoepidemiological Research in Older People, IRCCS – Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
    Search for articles by this author
  • on behalf of
    SIM-AF Investigators
    Authors List
    Published:April 12, 2018DOI:https://doi.org/10.1016/j.ejim.2018.04.006
        Atrial fibrillation (AF) is independently associated with a higher risk of morbidity and mortality, in particular with an increased risk of thromboembolic events [
        • Kirchhof P.
        • Benussi S.
        • Kotecha D.
        • Ahlsson A.
        • Atar D.
        • Casadei B.
        • et al.
        ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
        ]. Use of oral anticoagulant (OAC) drugs reduces the risk of stroke and systemic embolism, as well as mortality among patients with AF [
        • Kirchhof P.
        • Benussi S.
        • Kotecha D.
        • Ahlsson A.
        • Atar D.
        • Casadei B.
        • et al.
        ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
        ].

        Keywords

        To read this article in full you will need to make a payment

        Purchase one-time access:

        Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
        One-time access price info
        • For academic or personal research use, select 'Academic and Personal'
        • For corporate R&D use, select 'Corporate R&D Professionals'

        Subscribe:

        Subscribe to European Journal of Internal Medicine
        Already a print subscriber? Claim online access
        Already an online subscriber? Sign in
        Institutional Access: Sign in to ScienceDirect

        References

          • Kirchhof P.
          • Benussi S.
          • Kotecha D.
          • Ahlsson A.
          • Atar D.
          • Casadei B.
          • et al.
          ESC guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
          Eur. Heart J. 2016; 37: 2893-2962
          • Ruff C.T.
          • Giugliano R.P.
          • Braunwald E.
          • Hoffman E.B.
          • Deenadayalu N.
          • Ezekowitz M.D.
          • et al.
          Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials.
          Lancet. 2014; 383: 955-962
          • Boriani G.
          • Proietti M.
          • Laroche C.
          • Fauchier L.
          • Marin F.
          • Nabauer M.
          • et al.
          Contemporary stroke prevention strategies in 11 096 European patients with atrial fibrillation: a report from the EURObservational research Programme on atrial fibrillation (EORP-AF) long-term general registry.
          Europace. 2017 Sep; 14 ([Epub ahead of print])
          • Marcucci M.
          • Iorio A.
          • Nobili A.
          • Tettamanti M.
          • Pasina L.
          • Marengoni A.
          • et al.
          Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards.
          Eur. J. Intern. Med. 2010; 21: 516-523
          • Proietti M.
          • Nobili A.
          • Raparelli V.
          • Napoleone L.
          • Mannucci P.M.
          • Lip G.Y.H.
          • et al.
          Adherence to antithrombotic therapy guidelines improves mortality among elderly patients with atrial fibrillation: insights from the REPOSI study.
          Clin. Res. Cardiol. 2016; 105: 912-920
          • Marzec L.N.
          • Wang J.
          • Shah N.D.
          • Chan P.S.
          • Ting H.H.
          • Gosch K.L.
          • et al.
          Influence of direct oral anticoagulants on rates of oral anticoagulation for atrial fibrillation.
          J. Am. Coll. Cardiol. 2017; 69: 2475-2484
          • Lubitz S.A.
          • Bauer K.A.
          • Benjamin E.J.
          • Besdine R.W.
          • Forman D.E.
          • Gurol M.E.
          • et al.
          Stroke prevention in atrial fibrillation in older adults: existing knowledge gaps and areas for innovation: a summary of an American Federation for Aging research seminar.
          J. Am. Geriatr. Soc. 2013; 61: 1798-1803
          • Patti G.
          • Lucerna M.
          • Pecen L.
          • Siller-Matula J.M.
          • Cavallari I.
          • Kirchhof P.
          • et al.
          Thromboembolic risk, bleeding outcomes and effect of different antithrombotic strategies in very elderly patients with atrial fibrillation: a sub-analysis from the PREFER in AF (PREvention oF thromboembolic events-European registry in atrial fibrillation).
          J. Am. Heart Assoc. 2017; 6e005657
          • Hanon O.
          • Vidal J.-S.
          • Le Heuzey J.-Y.
          • Kirchhof P.
          • De Caterina R.
          • Schmitt J.
          • et al.
          Oral anticoagulant use in octogenarian European patients with atrial fibrillation: a subanalysis of PREFER in AF.
          Int. J. Cardiol. 2017; 232: 98-104
          • Huisman M.V.
          • Rothman K.J.
          • Paquette M.
          • Teutsch C.
          • Diener H.-C.
          • Dubner S.J.
          • et al.
          The changing landscape for stroke prevention in AF: findings from the GLORIA-AF registry phase 2.
          J. Am. Coll. Cardiol. 2017; 69: 777-785