Highlights
- •The prevalence of the ATP III-MetS is lower than that of the Asian-MetS.
- •Both MetS scores are strong risk factors for arterial stiffness and diabetes.
- •The performance of both MetS scores for arterial stiffness is similar.
- •The performance of both MetS scores for risk of diabetes is similar.
Abstract
Background
Published studies seldom tested the weight of different waist circumference (WC) cut-off
values for the diagnosis of metabolic syndrome (MetS) in predicting clinical outcomes,
including cardiovascular disease and diabetes.
Methods
This is a Chinese population-based cross-sectional study screening subjects from a
Health Examination Program since 1999 to 2015. The MetS identification and scores
were determined either according to the Adult Treatment Panel III/American Heart Association/National
Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI)- or Asian-WC cut-off points.
The developments of a higher brachial-ankle pulse wave velocity (baPWV), defined as
≥1400 cm/s, and diabetic-level hyperglycemia, defined as a high fasting glucose level
≥6.99 mmol/L or postprandial glucose level ≧11.10 mmol/L, were surveyed by comparing
the areas under receiver operating characteristic curves (AUC-ROC) for both MetS scores.
Results
According to the ATP III/AHA/NHLBI- vs Asian-MetS criteria, 6633 vs 9133 (24.8% vs
34.2%, p < 0.001) subjects were diagnosed as the MetS among 26,735 study subjects with a mean
age of 55 ± 12 years. The stepwise increases in baPWV and prevalence of diabetic-level
hyperglycemia were associated with both MetS scores after adjusting for age and sex.
Both MetS scores yielded similar results for correlation with a higher baPWV (AUC-ROC = 0.685
for ATP III/AHA/HLBI- vs 0.680 for Asian-MetS, p = 0.271) and diabetic-level hyperglycemia (AUC-ROC = 0.791 for ATP III/AHA/HLBI-
vs 0.784 for Asian-MetS, p = 0.546).
Conclusions
In a stepwise manner, both ATP III/AHA/NHLBI- or Asian-MetS scores were strong risk
factors for arterial stiffness and diabetes. Through a novel and holistic approach,
the performance of the ATP III/AHA/NHLBI-MetS score for the risks of arterial stiffness
and diabetes was comparable to the Asian-MetS score among a Chinese population.
Keywords
Abbreviations:
ABI (ankle-brachial-index), ASCVD (atherosclerotic cardiovascular disease), ATP III/AHA/NHLBI (Adult Treatment Panel III by the American Heart Association and the National Heart, Lung, and Blood Institute), AUC-ROC (areas under receiver operator characteristic curves), baPWV (brachial-ankle pulse wave velocity), HDL-C (high-density lipoprotein cholesterol), IDF (International Diabetes Federation), MetS (metabolic syndrome), SBP (systolic blood pressure), WC (waist circumferences)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: April 12, 2018
Accepted:
April 8,
2018
Received in revised form:
March 13,
2018
Received:
November 13,
2017
Identification
Copyright
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
