Large databases (Big Data) and evidence-based medicine

      Evidence-based medicine (EBM) is more than 30 years old and has led to enormous changes in medical approaches through the development of increasingly objective guidelines, based on the results of randomized clinical trials (RCTs) and meta-analyses [
      • Davidoff F.
      • Haynes B.
      • Sackett D.
      • Smith R.
      Evidence based medicine.
      ]. However, there are several concerns with the type of evidence that RCTs and meta-analyses provide.
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