Advertisement

Large databases (Big Data) and evidence-based medicine

      Evidence-based medicine (EBM) is more than 30 years old and has led to enormous changes in medical approaches through the development of increasingly objective guidelines, based on the results of randomized clinical trials (RCTs) and meta-analyses [
      • Davidoff F.
      • Haynes B.
      • Sackett D.
      • Smith R.
      Evidence based medicine.
      ]. However, there are several concerns with the type of evidence that RCTs and meta-analyses provide.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Davidoff F.
        • Haynes B.
        • Sackett D.
        • Smith R.
        Evidence based medicine.
        BMJ. 1995 Apr 29; 310: 1085-1086
        • Sheridan D.J.
        • Julian D.G.
        Achievements and limitations of evidence-based medicine.
        J Am Coll Cardiol. 2016 Jul 12; 68: 204-213
        • Crome P.
        • Lally F.
        • Cherubini A.
        • et al.
        Exclusion of older people from clinical trials: Professional views from nine European countries participating in the PREDICT study.
        Drugs Aging. 2011 Aug 1; 28: 667-677
        • Tinetti M.E.
        • Studenski S.A.
        Comparative effectiveness research and patients with multiple chronic conditions.
        N Engl J Med. 2011 Jun 30; 364: 2478-2481
        • Laney D.
        3D data management: Controlling data volume, velocity, and variety.
        in: Application delivery strategies by META Group Inc. 2001 Feb 6 ([949-5])
        • Tagliaferri L.
        • Gobitti C.
        • Colloca G.F.
        • Boldrini L.
        • Farina E.
        • Furlan C.
        • et al.
        A new standardized data collection system for interdisciplinary thyroid cancer management: Thyroid COBRA.
        Eur J Intern Med. 2018 Feb 21; (in press)
        • Angus D.C.
        Fusing randomized trials with Big Data: The key to self-learning health care systems?.
        JAMA. 2015 Aug 25; 314: 767-768