Nowadays, systemic thrombolysis remains the cornerstone in the treatment of different
life-threatening arterial occlusive disease as ischemic stroke and pulmonary embolism
(PE). Conversely, its use has scale down over the years in the treatment of acute
myocardial infarction (AMI) after the wide diffusion of percutaneous coronary artery
intervention (PCI) and Cath-labs [
[1]
]. Thrombolytic treatments have been widely investigated both from a clinical and
biochemical point of view [
[2]
]. However, the rheological properties of thrombolytic agents are often not well known
or ignored by physicians since their description require the understanding of complex
mathematical models. Moreover, most of these investigations have been often published
in in biophysics or math journals, which are generally not of interest for physicians.
The physical and rheological properties of thrombolytic agents have been studied both
in-vivo and in-vitro using different imaging modalities as optical photography and
magnetic resonance imaging (MRI) [
[3]
,
[4]
]. Why a physician should be interested in the physic properties of thrombolytic agents?
Because the knowledge of the interaction between the drug and the thrombus could be
helpful to understand and even explain some events which can occur in their daily
clinical practice.Keywords
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References
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- A concept of thrombolysis as a corrosion-erosion process verified by optical microscopy.Microcirculation. 2012; 19: 632-641
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- Modelling the effect of laminar axially directed blood flow on the dissolution of non-occlusive blood clots.Phys Med Biol. 2007; 52: 2969-2985
Article info
Publication history
Published online: June 09, 2018
Accepted:
June 5,
2018
Received:
June 3,
2018
Identification
Copyright
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
