Pulmonary arterial hypertension (PAH) is a progressive disease of the small pulmonary
arteries characterized by vascular proliferation and remodelling, increased pulmonary
vascular resistances (PVR) and endothelial dysfunction [
[1]
]. Over the last years, an increasing attention has been posed on the use of computational
fluid dynamic analysis (CFD) in the field of cardiovascular medicine [
[2]
], and a growing attention has emerged also in the analysis of PAH. Different studies,
using both CFD analysis and 4D-flow magnetic resonance (MRI), have demonstrated that
the wall shear stress (WSS), a well-known force in cardiovascular disease, is involved
both in the progression and maintenance of PAH [
[3]
,
[4]
]. Indeed, CFD results have demonstrated that WSS in the pulmonary arteries of PAH
patients was lower than in healthy subjects [
[5]
]. Current diagnostic techniques used to assess and monitoring both PAH severity and
therapy efficacy, as transthoracic echocardiography (TTE) and right heart catheterization
(RHC) are graved by several drawbacks including operator's dependence and expertise.Keywords
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References
- Pulmonary arterial hypertension: the clinical syndrome.Circ Res. 2014; 115: 115-130
- Mathematics and cardiovascular interventions: Role of the finite element modeling in clinical decision making.JACC Cardiovasc Interv. 2016; 9: 507-508
- Four-dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: results from two institutions.Magn Reson Med. 2015; 73: 1904-1913
- Wall shear stress is decreased in the pulmonary arteries of patients with pulmonary arterial hypertension: an image-based, computational fluid dynamics study.Pulm Circ. 2012; 2: 470-476
- Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension.J Cardiovasc Magn Reson. 2013; 15: 81
Article info
Publication history
Published online: June 11, 2018
Accepted:
June 5,
2018
Received:
June 3,
2018
Identification
Copyright
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
