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The association between bowel obstruction and the management of cholelithiasis and cholecystitis in elderly patients: A population-based cohort study

  • Yen-Chun Peng
    Affiliations
    Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    National Yang-Ming University, Taipei, Taiwan
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  • Cheng-Li Lin
    Affiliations
    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    College of Medicine, China Medical University, Taichung, Taiwan
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  • Hong-Zen Yeh
    Affiliations
    Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

    National Yang-Ming University, Taipei, Taiwan
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  • Chi-Sen Chang
    Affiliations
    Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
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  • Chia-Hung Kao
    Correspondence
    Corresponding author at: Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.
    Affiliations
    Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

    Department of Nuclear Medicine, PET Center, China Medical University Hospital, Taichung, Taiwan

    Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan
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      Highlights

      • Obstruction: 24.6, 19.2, 13.6/1000 for PTGBD, cholecystectomy, laparoscopic cholecystectomy.
      • Compared with PTGBD, HR was 0.77 and 0.57 for cholecystectomy, laparoscopic cholecystectomy.
      • Subsequent cholecystectomy could benefit with a lower risk of bowel events.

      Abstract

      Aims

      This study aimed to evaluate the risk of bowel events among elderly patients treated using only PTGBD (Percutaneous Gallbladder Drainage), or a cholecystectomy on its own, or PTGBD combined with a subsequent cholecystectomy.

      Methods

      A retrospective population-based cohort study was conducted with newly diagnosed cholelithiasis and cholecystitis patients who had no bowel obstruction history and were aged over 65 years during the period of January 1, 2000 to December 31, 2010. These patients were placed into 3 separate study cohorts; PTGBD alone, cholecystectomy alone and PTGBD with subsequent laparoscopic cholecystectomy, with the cohort frequencies matched by age and gender. We defined the index date as the time of the initial cholelithiasis and cholecystitis diagnosis date and began observation and suspended follow-up when the patient had either withdrawn from their health insurance, developed bowel obstruction or reached the date of December 31, 2011.

      Results

      The incidences of bowel obstruction were 24.6, 19.2 and 13.6 per 1000 person-years for PTGBD cohort, cholecystectomy cohort and PTGBD respectively, with a subsequent laparoscopic cholecystectomy cohort. Compared with the PTGBD cohort, (which was adjusted for age, gender, CCI score and laparotomy history), the hazard ratio of bowel obstruction was 0.77 (95% Confidence Interval (CI) = 0.59–1.00) and 0.57 (95% CI = 0.43–0.76) for the cholecystectomy cohort and PTGBD with a subsequent laparoscopic cholecystectomy cohort respectively.

      Conclusion

      For treatment of cholelithiasis and cholecystitis in elderly patients, PTGBD with a subsequent cholecystectomy could benefit patients by providing a lower risk of ileus or intestinal obstruction.

      Keywords

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