Highlights
- •The annual rate of GFR decline is lower among IFG patients in comparison to control
- •This effect was shown among men but not among women
- •A mechanism of glomerular hyperfiltration might explain our results
Abstract
Objectives
Early stages of diabetes are associated with an increased glomerular filtration rate
(GFR). Little is known, however, about the change in GFR among patients with impaired
fasting glucose (IFG). We aimed to evaluate the yearly decline rate of GFR among IFG
patients.
Methods
A retrospective analysis of a large cohort of subjects attending a medical screening
center in Israel. Patients with diabetes mellitus and patients with decreased estimated
GFR (eGFR) were excluded. We divided the cohort into 2 subgroups; Healthy controls
and impaired fasting control subjects. For each group, we calculated the average yearly
estimated GFR decline (ΔeGFR). The results were adjusted for age, BMI, hypertension
and smoking status.
Results
8176 subjects met the inclusion criteria. The median follow up time was 4.8 years
(range 2.0 to 13.4). For the whole cohort (men and women), yearly ΔeGFR was −0.68
among healthy controls, and − 0.47 among IFG patients (p = .003). Among men, average yearly ΔeGFR in healthy controls and IFG patients was
−0.7 and − 0.4, respectively (p = .0002). All results remained significant after adjusting for age, BMI, hypertension,
smoking status and level of HDL and triglycerides. In contrast, among IFG women there
was no significant difference in ΔeGFR in comparison with healthy women.
Conclusions
Impaired fasting glucose is associated with a decreased rate of GFR reduction compared
with healthy subjects. This effect is gender dependent - observed in men but not in
women. A mechanism of glomerular hyperfiltration might be involved.
Keywords
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Article info
Publication history
Published online: July 18, 2018
Accepted:
July 10,
2018
Received in revised form:
June 7,
2018
Received:
January 8,
2018
Identification
Copyright
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
