Advertisement

Minor salivary gland biopsy is more effective than normal appearing skin biopsy for amyloid detection in systemic amyloidosis: A prospective monocentric study

Published:August 01, 2018DOI:https://doi.org/10.1016/j.ejim.2018.07.026
      The term “amyloidosis” encompasses a large group of diseases characterized by extracellular deposition of fibrillar proteins impairing organ function. Classification of amyloidosis relies on the nature of the protein and the deposition site. Systemic amyloidosis includes mainly immunoglobulin light chains (AL) amyloidosis, transthyretin (TTR) amyloidosis, either wild-type or hereditary, and “reactive” amyloid A (AA) amyloidosis [
      • Sipe J.D.
      • Benson M.D.
      • Buxbaum J.N.
      • et al.
      Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 nomenclature guidelines.
      ,

      G. Husby, Robert A. Kyle MD. Nomenclature and classification of amyloid and amyloidoses. J Intern Med 1992;232(6):511–2.

      ].

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Sipe J.D.
        • Benson M.D.
        • Buxbaum J.N.
        • et al.
        Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 nomenclature guidelines.
        Amyloid. 2016; 23: 209-213
      1. G. Husby, Robert A. Kyle MD. Nomenclature and classification of amyloid and amyloidoses. J Intern Med 1992;232(6):511–2.

        • Jamet M.P.
        • Gnemmi V.
        • Hachulla E.
        • et al.
        Distinctive patterns of transthyretin amyloid in salivary tissue: a clinicopathologic study of 92 patients with amyloid-containing minor salivary gland biopsies.
        Am J Surg Pathol. 2015; 39: 1035-1044
        • Westermark P.
        Occurrence of amyloid deposits in the skin in secondary systemic amyloidosis.
        Acta Pathol Microbiol Scand A. 1972; 80: 718-720
        • Rubinow A.
        • Cohen A.S.
        Skin involvement in generalized amyloidosis. A study of clinically involved and uninvolved skin in 50 patients with primary and secondary amyloidosis.
        Ann Intern Med. 1978; 88: 781-785
        • Lee D.D.
        • Huang C.Y.
        • Wong C.K.
        Dermatopathologic findings in 20 cases of systemic amyloidosis.
        Am J Dermatopathol. 1998; 20: 438-442
        • Foli A.
        • Palladini G.
        • Caporali R.
        • et al.
        The role of minor salivary gland biopsy in the diagnosis of systemic amyloidosis: results of a prospective study in 62 patients.
        Amyloid. 2011; 18: 80-82
        • Suzuki T.
        • Kusumoto S.
        • Yamashita T.
        • et al.
        Labial salivary gland biopsy for diagnosing immunoglobulin light chain amyloidosis: a retrospective analysis.
        Ann Hematol. 2016; 95: 279-285
        • Mercan R.
        • Bıtık B.
        • Tezcan M.E.
        • et al.
        Minimally invasive minor salivary gland biopsy for the diagnosis of amyloidosis in a rheumatology clinic.
        ISRN Rheumatol. 2014; 2014: 354648
        • Fatihi E.
        • Zahiri K.
        • Hachim K.
        • et al.
        Intérêt de la biopsie des glandes salivaires accessoires dans l'amylose. [Value of the biopsy of accessory salivary glands in amyloidosis].
        Rev Med Interne. 1999; 20: 759-761