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High fractional potassium excretion in symptomatic hyponatremia

  • Wim Musch
    Affiliations
    Department of Internal Medicine, Bracops Hospital, Brussels, Belgium

    Research Unit for the Study of Hydromineral Metabolism, Department of Internal Medicine, Erasmus University Hospital, Free University of Brussels, ULB, Brussels, Belgium
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  • Guy Decaux
    Correspondence
    Corresponding author at: Department of Internal Medicine, Erasmus University Hospital Route de Lennik, 8081070 Brussels, Belgium.
    Affiliations
    Research Unit for the Study of Hydromineral Metabolism, Department of Internal Medicine, Erasmus University Hospital, Free University of Brussels, ULB, Brussels, Belgium
    Search for articles by this author
Published:September 08, 2018DOI:https://doi.org/10.1016/j.ejim.2018.09.002
      In experimental SIADH induce in man [
      • Stormont J.M.
      • Waterhouse C.
      The genesis of hyponatremia associated with marked overhydratation and water intoxication.
      ] or animal [
      • Verbalis J.G.
      • Drutarosky M.D.
      Adaptation to chronic hypoosmolality in rats.
      ,
      • Gowrishankar M.
      • Chen C.B.
      • Mallie J.P.
      • Halperin M.L.
      What is the impact of potassium excretion on the intracellular fluid volume: importance of urine anions.
      ,
      • Gankam-Kengne F.
      • Decaux G.
      Hyponatremia and the brain.
      ] it is well know that not only sodium excretion increase during a few days (particularly if it is acute), the same as been reported for potassium excretion although to a lesser extent. This high potassium excretion is considered to reflect cell adaptation to hypotonicity, it is usually transient (a few days) and depends on the speed by which SNa is decreasing [
      • Verbalis J.G.
      • Drutarosky M.D.
      Adaptation to chronic hypoosmolality in rats.
      ,
      • Gowrishankar M.
      • Chen C.B.
      • Mallie J.P.
      • Halperin M.L.
      What is the impact of potassium excretion on the intracellular fluid volume: importance of urine anions.
      ,
      • Gankam-Kengne F.
      • Decaux G.
      Hyponatremia and the brain.
      ].

      Keywords

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