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The geriatric condition of frailty

Published:September 22, 2018DOI:https://doi.org/10.1016/j.ejim.2018.09.011
      Frailty is a clinical condition characterized by a decrease of reserves and functions across multiple physiological systems, responsible for a compromised ability to cope with stressors [
      • Clegg A.
      • Young J.
      • Iliffe S.
      • Rikkert M.O.
      • Rockwood K.
      Frailty in elderly people.
      ]. Frailty is highly prevalent in older persons [
      • Collard R.M.
      • Boter H.
      • Schoevers R.A.
      • Oude Voshaar R.C.
      Prevalence of frailty in community-dwelling older persons: a systematic review.
      ,
      • Santos-Eggimann B.
      • Cuenoud P.
      • Spagnoli J.
      • Junod J.
      Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries.
      ], and is associated with a higher risk of adverse outcomes (including death, falls, fractures, hospitalization, and disability) [
      • Clegg A.
      • Young J.
      • Iliffe S.
      • Rikkert M.O.
      • Rockwood K.
      Frailty in elderly people.
      ,
      • Fried L.P.
      • Tangen C.M.
      • Walston J.
      • et al.
      Frailty in older adults: evidence for a phenotype.
      ,
      • Beard J.R.
      • Officer A.
      • de Carvalho I.A.
      • et al.
      The World report on ageing and health: a policy framework for healthy ageing.
      ]. It is, thus, evident why it is increasingly considered an important public health problem. In this special issue, we present a set of articles spanning over different aspects of frailty research, from its definition and measurement, to the identification of risk factors and promising biomarkers, up to ad hoc interventions and treatment.
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      References

        • Clegg A.
        • Young J.
        • Iliffe S.
        • Rikkert M.O.
        • Rockwood K.
        Frailty in elderly people.
        Lancet. 2013; 381 ([London, England]): 752-762
        • Collard R.M.
        • Boter H.
        • Schoevers R.A.
        • Oude Voshaar R.C.
        Prevalence of frailty in community-dwelling older persons: a systematic review.
        J. Am. Geriatr. Soc. 2012; 60: 1487-1492
        • Santos-Eggimann B.
        • Cuenoud P.
        • Spagnoli J.
        • Junod J.
        Prevalence of frailty in middle-aged and older community-dwelling Europeans living in 10 countries.
        J. Gerontol. A Biol. Sci. Med. Sci. 2009; 64: 675-681
        • Fried L.P.
        • Tangen C.M.
        • Walston J.
        • et al.
        Frailty in older adults: evidence for a phenotype.
        J. Gerontol. A Biol. Sci. Med. Sci. 2001; 56: M146-M156
        • Beard J.R.
        • Officer A.
        • de Carvalho I.A.
        • et al.
        The World report on ageing and health: a policy framework for healthy ageing.
        Lancet. 2016; 387 ([London, England]): 2145-2154
        • Junius-Walker U.
        • Onder G.
        • Soleymani D.
        • et al.
        The essence of frailty: a systematic review and qualitative synthesis on frailty concepts and definitions.
        Eur J Intern Med. 2018;
        • Mitnitski A.B.
        • Mogilner A.J.
        • Rockwood K.
        Accumulation of deficits as a proxy measure of aging.
        TheScientificWorldJOURNAL. 2001; 1: 323-336
        • Cesari M.
        • Franchi C.
        • Cortesi L.
        • et al.
        Implementation of the frailty index in hospitalized older patients: results from the REPOSI register.
        Eur J Intern Med. 2018;
        • Calvani R.
        • Picca A.
        • Marini F.
        • et al.
        The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: rationale, design and methods.
        Eur J Intern Med. 2018;
        • Gabrovec B.
        • Veninsek G.
        • Samaniego L.L.
        • Carriazo A.M.
        • Antoniadou E.
        • Jelenc M.
        The role of nutrition in ageing: a narrative review from the perspective of the European joint action on frailty - ADVANTAGE JA.
        Eur J Intern Med. 2018;
        • Villani E.R.
        • Tummolo A.M.
        • Palmer K.
        • et al.
        Special issue frailty - frailty and atrial fibrillation: a systematic review.
        Eur J Intern Med. 2018;
        • Corsonello A.
        • Roller-Wirnsberger R.
        • Di Rosa M.
        • et al.
        Estimated glomerular filtration rate and functional status among older people: a systematic review.
        Eur J Intern Med. 2018;
        • Onder G.
        • Vetrano D.L.
        • Marengoni A.
        • et al.
        Accounting for frailty when treating chronic diseases.
        Eur J Intern Med. 2018;
        • Vetrano D.L.
        • Palmer K.
        • Marengoni A.
        • et al.
        Frailty and multimorbidity: a systematic review and meta-analysis.
        J. Gerontol. A Biol. Sci. Med. Sci. 2018; https://doi.org/10.1093/gerona/gly110
        • Zucchelli A.
        • Vetrano D.L.
        • Marengoni A.
        • et al.
        Frailty predicts short-term survival even in older adults without multimorbidity.
        Eur J Intern Med. 2018;
        • Inzitari M.
        • Perez L.M.
        • Enfedaque M.B.
        • et al.
        Integrated primary and geriatric care for frail older adults in the community: implementation of a complex intervention into real life.
        Eur J Intern Med. 2018;