Highlights
- •An association between heat stroke episodes and IHD events was seen.
- •The onset of IHD in patients with heat stroke was earlier than without heat stroke.
- •Being vigilant about the atherosclerotic complications in patients with heat stroke.
Abstract
The purpose of this study is to determine the relationship between heat stroke and
ischemic heart disease (IHD), in a nationwide population using a longitudinal approach.
We retrospectively examined the data from the National Health Insurance Research Database
(NHIRD) in Taiwan, for patients examined between 2000 and 2013. In total, 628 patients
with a heat stroke episode were enrolled and matched with 1256 patients without any
history of a heat stroke episode by propensity score matching at a ratio of 1:2. The
mean follow-up years of the heat stroke group was 11.89 years and the mean follow
up of the control group was 11.51 years. An association between heat stroke episodes
and IHD (log-rank p < .001) was found in a univariate cox regression analysis. After multivariate adjustment,
age, comorbidities (hypertension, diabetes, stroke), and lower insurance premiums
were associated with IHD events in patients who had a heat stroke. IHD was independently
associated with heat stroke following cox multivariate regression analysis and patients
with a heat stroke episode had a higher incidence of IHD events compared to those
without any heat stroke episode (2598.41/105 person-years vs. 1286.14/105 person-years, adjusted hazard ratio 3.527, 95% CI: 2.078–4.032, p < .001). The onset of IHD in patients who suffered a heat stroke was earlier than
in those without a heat stroke episode (2.08 ± 3.45 vs. 3.61 ± 3.25 years, p < .001).
In conclusion, clinicians should be aware about evaluating the IHD risk following
a heat stroke episode in a patient.
Keywords
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Article info
Publication history
Published online: October 05, 2018
Accepted:
September 27,
2018
Received in revised form:
September 21,
2018
Received:
May 3,
2018
Identification
Copyright
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
