We read the study of Calvania et al. with great interest titled “BIOmarkers associated
with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE): Rationale, design
and methods” [
[1]
]. In this paper, the authors highlighted that sarcopenia was a major health issue
in older adults given its high prevalence, and burdensome clinical implications. In
addition to this unsolved debate, the complexity of musculoskeletal ageing represented
a major challenge to the identification of clinically meaningful biomarkers. This
was a well-designed study which illustrated the advantages of biomarker discovery
procedures in muscle ageing based on multivariate methodologies as an alternative
approach to traditional single-marker strategies.To read this article in full you will need to make a payment
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References
- The “BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE) study: rationale, design and methods.Eur J Intern Med. 2018; 56: 19-25https://doi.org/10.1016/j.ejim.2018.05.001
- Frailty in older adults: evidence for a phenotype.J Gerontol A Biol Sci Med Sci. 2001; 56: 146-157https://doi.org/10.1093/gerona/56.3.M146
- A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans.J Nutr Health Aging. 2012; 16: 601-608https://doi.org/10.1007/s12603-012-0084-2
- Frailty consensus: a call to action.J Am Med Dir Assoc. 2013; 14: 392-397https://doi.org/10.1016/j.jamda.2013.03.022
Article info
Publication history
Published online: November 14, 2018
Accepted:
November 11,
2018
Received in revised form:
October 31,
2018
Received:
October 17,
2018
Identification
Copyright
© 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- In reply to “Small, however significant differences in the definition of physical frailty and sarcopenia”European Journal of Internal MedicineVol. 61
- PreviewWe thank Dr. Yilmaz and colleagues [1] for their comment that allows us to further clarify a major strength of the BIOSPHERE study [2]. Many operational definitions of frailty exist, each of them describing specific aspects of the condition and capturing different risk profiles. The two constructs mentioned by the authors (i.e., the phenotype proposed by Fried et al. [3] and the FRAIL criteria designed by Morley [4]) are not gold standards for the assessment of physical frailty, simply because no reference tool is recognized in this field.
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