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Letter to the Editor| Volume 62, e16, April 2019

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Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation

  • Vera R. Bernardino
    Correspondence
    Corresponding author at: Serviço Medicina Interna 7.2, Hospital Curry Cabral, Rua da Beneficência 8, 1069-166 Lisboa, Portugal.
    Affiliations
    Unidade de Doenças Auto-Imunes, Internal Medicine Department 7.2, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisboa, Portugal
    Search for articles by this author
  • Ana Catarina Rodrigues
    Affiliations
    Unidade de Doenças Auto-Imunes, Internal Medicine Department 7.2, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisboa, Portugal
    Search for articles by this author
  • António Panarra
    Affiliations
    Unidade de Doenças Auto-Imunes, Internal Medicine Department 7.2, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisboa, Portugal
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Published:February 06, 2019DOI:https://doi.org/10.1016/j.ejim.2019.02.001
Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation
Previous ArticlePhysiological reaction following contrast medium administration: What kind of reaction is this?
Next ArticleManagement of celiac disease in daily clinical practice: do not forget depression!
      Vascular pathology is increasingly more recognized as an extra-intestinal manifestation of Inflammatory Bowel Disease (IBD) [
      • Koutroubakis I.E.
      • Sfiridaki A.
      • Tsiolakidou G.
      • et al.
      Genetic risk factors in patients with inflammatory bowel disease and vascular complications: case-control study.
      Inflamm Bowel Dis. 2007; 13: 410-415https://doi.org/10.1002/ibd.20076
      ,
      • Tan V.
      • Chung A.
      • Yan B.P.
      • et al.
      Venous and arterial disease in inflammatory bowel disease.
      J Gastroenterol Hepatol. 2013; 28: 1095-1113https://doi.org/10.1111/jgh.12260
      ]. Raynaud's phenomenon (RP), a syndrome characterized by recurrent episodes of digital artery vasospasm, may be secondary to systemic diseases and is rarely associated with IBD [
      • Prete M.
      • Fatone M.C.
      • Favoino E.
      • et al.
      Raynaud's phenomenon: from molecular pathogenesis to therapy.
      Autoimmun Rev. 2014; 13: 655-667https://doi.org/10.1016/j.autrev.2013.12.001
      ,
      • Karmiris K.
      • Avgerinos A.
      • Tavernakari A.
      • et al.
      Prevalence and characteristics of extra-intestinal manifestations in a large cohort of greek patients with inflammatory bowel disease.
      J Crohns Colitis. 2016; 10: 429-436https://doi.org/10.1093/ecco-jcc/jjv232
      ]. RP occurs in the presence of abnormalities of dermal capillaries, the morphology of which can be examined by nailfold capillaroscopy (NFC), a standardized non-invasive technique [
      • Cutolo M.
      • Sulli A.
      • Smith V.
      How to perform and interpret capillaroscopy.
      Best Pract Res Clin Rheumatol. 2013; 27: 237-248https://doi.org/10.1016/j.berh.2013.03.001
      ].

      Keywords

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      References

        • Koutroubakis I.E.
        • Sfiridaki A.
        • Tsiolakidou G.
        • et al.
        Genetic risk factors in patients with inflammatory bowel disease and vascular complications: case-control study.
        Inflamm Bowel Dis. 2007; 13: 410-415https://doi.org/10.1002/ibd.20076
        View in Article
        • Tan V.
        • Chung A.
        • Yan B.P.
        • et al.
        Venous and arterial disease in inflammatory bowel disease.
        J Gastroenterol Hepatol. 2013; 28: 1095-1113https://doi.org/10.1111/jgh.12260
        View in Article
        • Prete M.
        • Fatone M.C.
        • Favoino E.
        • et al.
        Raynaud's phenomenon: from molecular pathogenesis to therapy.
        Autoimmun Rev. 2014; 13: 655-667https://doi.org/10.1016/j.autrev.2013.12.001
        View in Article
        • Karmiris K.
        • Avgerinos A.
        • Tavernakari A.
        • et al.
        Prevalence and characteristics of extra-intestinal manifestations in a large cohort of greek patients with inflammatory bowel disease.
        J Crohns Colitis. 2016; 10: 429-436https://doi.org/10.1093/ecco-jcc/jjv232
        View in Article
        • Cutolo M.
        • Sulli A.
        • Smith V.
        How to perform and interpret capillaroscopy.
        Best Pract Res Clin Rheumatol. 2013; 27: 237-248https://doi.org/10.1016/j.berh.2013.03.001
        View in Article
        • Cutolo M.
        • et al.
        Atlas of Capillaroscopy in Rheumatic Diseases.
        Elsevier, 2010 (eBook ISBN: 9788821433917)
        View in Article

      Article info

      Publication history

      Published online: February 06, 2019
      Accepted: February 1, 2019
      Received: December 9, 2018

      Identification

      DOI: https://doi.org/10.1016/j.ejim.2019.02.001

      Copyright

      © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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