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Relative fat mass (RFM) as abdominal obesity criterion for metabolic syndrome

Published:March 08, 2019DOI:https://doi.org/10.1016/j.ejim.2019.03.002
      Obesity is a recognized risk factor for various cardio-metabolic diseases and several indices are used clinically to assess overall cardio-metabolic risk [
      • Langenberg C.
      • Sharp S.J.
      • Schulze M.B.
      • Rolandsson O.
      • Overved K.
      • et al.
      Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct casecohort study.
      ]. The metabolic syndrome, which is an independent risk factor for coronary heart disease, peripheral artery disease, stroke and total mortality [
      • Athyros Vasilios G.
      • Ganotakis Emmanuel S.
      • Elisaf Moses S.
      • Liberopoulos Evangelos N.
      • Goudevenos Ioannis A.
      • Karagiannis Asterios
      Prevalence of vascular disease in metabolic syndrome using three proposed definitions.
      ,
      • Alexander Charles M.
      • Landsman Pamela B.
      • Teutsch Steven M.
      • Haffner Steven M.
      NCEP-defined metabolic syndrome, diabetes,and prevalence of coronary heart disease among NHANES III participants age 50 years and older.
      ,
      • Malik Shaista
      • Wong Nathan D.
      • Franklin Stanley S.
      • Kamath Tripthi V.
      • L'Italien Gilbert J.
      • Pio Jose R.
      • et al.
      Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults.
      ,
      • Scuteri A.
      • Najjar S.S.
      • Morrell C.H.
      • Lakatta E.G.
      The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the cardiovascular health study.
      ], was defined by the Adult Treatment Panel III (ATP III) as at least three of the five conditions – central obesity (as defined by men waist circumference > 40 in. or women waist circumference > 35 in.), raised triglycerides (above 150 mg/DL or on treatment), reduce HDL (below 40 mg/DL for men or 50 mg/DL for women), raised blood pressure (above 130/85mmHG or on treatment) and abnormal fasting plasma glucose (above 110 mg/DL or on treatment) [
      • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
      Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Final report.
      ].

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