Highlights
- •Cardiovascular disease in COPD patients not vaccinated with VNC13 and the exacerbator phenotype are related with the need of hospital admission.
- •VNC13 reduces the risk of hospital admission in non-exacerbator phenotype patients with COPD and established cardiovascular disease.
- •The detected benefit may be related to vaccine-induced immunity and its possible cardioprotective effect.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Consensus document on pneumococcal vaccination in adults at risk by age and underlying clinical conditions. 2017 update.Rev Esp Quimioter. 2017; 30: 142-168
- Rates of pneumococcal disease in adults with chronic medical conditions.Open Forum Infect Dis. 2014; 1ofu024
- Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD.Eur Respir J. 2008; 32: 962-969
- Impact of 13-valent pneumococal conjugate polysaccharide vaccination in exacerbations rate of COPD patients with moderate to severe obstruction.Rev Esp Quimioter. 2017; 30: 269-275
- Recommendations on non-pharmacological treatment in chronic obstructive pulmonary disease from the Spanish COPD guidelines (GesEPOC 2017).Arch Bronconeumol. 2018; 54: 568-575
- Bacteria in exacerbations of chronic obstructive pulmonary disease: phenomenon or epiphenomenon?.Proc Am Thorac Soc. 2004; 1: 109-114
- Association between hospitalization from pneumonia and subsequent risk of cardiovascular disease.JAMA. 2015; 313: 264-274
- Effect of the adult pneumococcal polysaccharide vaccine on cardiovascular disease: a systematic review and meta-analysis.Open Heart. 2015; 2e000247
- Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.Nat Med. 2003; 9: 736-743
- Pneumococcal vaccination and risk of myocardial infarction.CMAJ. 2008; 179: 773-777
Article info
Publication history
Published online: March 20, 2019
Accepted:
March 13,
2019
Received:
February 20,
2019
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
