Highlights
- •The Fat-to-Muscle ratio mirrors the imbalance between total body fat and lean mass.
- •The Fat-to-Muscle index correlates with all glucose metabolic disorders.
- •The Fat-to-Muscle ratio is associated to diabetes and all categories of prediabetes.
Abstract
Objective
The aim was to evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to
glucose metabolic disorders (GMD).
Design
Cross-sectional population based study.
Methods
Eligible subjects were healthy men and non-pregnant women with new diagnosis of GMD
that were allocated into following groups: 1) Normal Glucose Tolerance (NGT), 2) Diabetes,
3) impaired fasting glucose (IFG) + impaired glucose tolerance (IGT), 4) IGT, and
5) IFG. The FyM index [Total body fat (Kg)/total lean mass (Kg)], and the odds ratio
(OR) between FyM index and GMD were estimated.
Results
A total of 875 individuals with average age 41.62 ± 12.3 were enrolled; of them, 645
(73.1%) women and 230 (22.8%) men; 521 (59.5%), 71 (8.1%), 85 (9.7%), 53 (6.0%), and
145 (16.6%) individuals were allocated into groups with NGT, diabetes, IFG + IGT,
IGT, and IFG, respectively. The FyM was significantly associated with prediabetes
and diabetes in women (OR 4.2; 95%CI 3.0–11.1 and OR = 7.2; 95%CI 2.0–15.2) and men (OR = 2.6; 95%CI 1.1–6.7 and OR = 4.6; 95%CI 1.4–15.1). In the overall population, the OR between FyM index with IGT, IFG, and
IFG + IGT was 8.4 (95%CI 2.6–17.4), 5.2 (95%CI 2.6–10.6), and 6.1 (95%CI 1.8–9.5).
Conclusion
The FyM index was strongly associated with all categories of GMD.
Keywords
Abbreviations:
FyM (Fat-to-Lean Mass), GMD (metabolic disorders), NGT (Normal Glucose Tolerance), IFG (impaired fasting glucose), IGT (impaired glucose tolerance), OR (odds ratio), FPG (fasting plasma glucose), BMI (body mass index), WC (waist circumference), 95% CI (Confidence Interval)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: April 02, 2019
Accepted:
March 28,
2019
Received in revised form:
January 21,
2019
Received:
July 17,
2018
Identification
Copyright
© 2019 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.
