The fat-to-lean mass ratio, a novel anthropometric index, is associated to glucose metabolic disorders

Published:April 02, 2019DOI:


      • The Fat-to-Muscle ratio mirrors the imbalance between total body fat and lean mass.
      • The Fat-to-Muscle index correlates with all glucose metabolic disorders.
      • The Fat-to-Muscle ratio is associated to diabetes and all categories of prediabetes.



      The aim was to evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to glucose metabolic disorders (GMD).


      Cross-sectional population based study.


      Eligible subjects were healthy men and non-pregnant women with new diagnosis of GMD that were allocated into following groups: 1) Normal Glucose Tolerance (NGT), 2) Diabetes, 3) impaired fasting glucose (IFG) + impaired glucose tolerance (IGT), 4) IGT, and 5) IFG. The FyM index [Total body fat (Kg)/total lean mass (Kg)], and the odds ratio (OR) between FyM index and GMD were estimated.


      A total of 875 individuals with average age 41.62 ± 12.3 were enrolled; of them, 645 (73.1%) women and 230 (22.8%) men; 521 (59.5%), 71 (8.1%), 85 (9.7%), 53 (6.0%), and 145 (16.6%) individuals were allocated into groups with NGT, diabetes, IFG + IGT, IGT, and IFG, respectively. The FyM was significantly associated with prediabetes and diabetes in women (OR 4.2; 95%CI 3.0–11.1 and OR = 7.2; 95%CI 2.0–15.2) and men (OR = 2.6; 95%CI 1.1–6.7 and OR = 4.6; 95%CI 1.4–15.1). In the overall population, the OR between FyM index with IGT, IFG, and IFG + IGT was 8.4 (95%CI 2.6–17.4), 5.2 (95%CI 2.6–10.6), and 6.1 (95%CI 1.8–9.5).


      The FyM index was strongly associated with all categories of GMD.



      FyM (Fat-to-Lean Mass), GMD (metabolic disorders), NGT (Normal Glucose Tolerance), IFG (impaired fasting glucose), IGT (impaired glucose tolerance), OR (odds ratio), FPG (fasting plasma glucose), BMI (body mass index), WC (waist circumference), 95% CI (Confidence Interval)
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