Highlights
- •The higher of serum myostatin the more serious of heart failure
- •High serum myostatin related to elevated died or rehospitalization rate.
- •Myostatin reflected the severity and prognosis of heart failure.
Abstract
Background
The exact relationship between serum myostatin and the severity and prognosis of chronic
heart failure (CHF) is unclear. In this study, we investigated the association between
serum myostatin and the severity and prognosis in patients with CHF.
Methods
Two hundred and eighty-eight CHF patients and 62 healthy controls were studied. Cardiac
ultrasound and serum myostatin, N-terminal pro-B-type natriuretic peptide (NT-proBNP)
and other parameters were detected. CHF patients were divided into 3 groups according
to tertiles of NT-proBNP or myostatin levels respectively.
Results
Serum myostatin levels were higher in CHF patients than in controls. New York Heart
Association (NYHA) class IV patients had the highest levels of serum myostatin among
the four NYHA classes. Compared with the low tertile NT-proBNP group, serum myostatin
levels were significantly higher in the moderate and high tertile groups (15.47 ± 4.25
vs. 14.18 ± 3.69 ng/mL, p = .026; 16.28 ± 5.34 vs. 14.18 ± 3.69 ng/mL, p = .002). During 51-months follow-up, of 173 patients there were 36 deaths. Compared
to survivors, nonsurvivors had significantly higher serum myostatin (18.11 ± 4.52
vs. 14.85 ± 5.11 ng/mL, p < .01). Patients in the high tertile myostatin group had lower survival rate (73.95%
vs. 93.75%; p < .05) and larger number of CHF rehospitalization than those in the low tertile group.
Cox regression analysis showed that serum myostatin was an independent predictor of
mortality.
Conclusions
Serum myostatin levels can reflect the severity of CHF and be a predictor of adverse
prognosis in CHF patients.
Keywords
Abbreviations:
CHF (chronic heart failure), NYHA (New York Heart Association), NT-proBNP (N-terminal pro-B-type natriuretic peptide), LVEF (left ventricular ejection fraction), ROC (receiver operating characteristic), IHD (ischemic heart disease), AUC (area under the curve.)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 02, 2019
Accepted:
April 24,
2019
Received in revised form:
April 1,
2019
Received:
October 30,
2018
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
