Highlights
- •HAE may lead to substantial use of call center mainly driven by abdominal attacks.
- •Call center can dispatch EMS when edema attacks can be potentially life threatening.
- •The management of HAE attacks is shortened by the call center.
- •Use of ED and hospitalizations are reduced by the use of a national call center in HAE.
Abstract
Objective
Hereditary angiœdema (HAE) is a rare autosomal dominant disease characterized by recurrent,
unpredictable, potentially life-threatening swelling. Objective is to assess the management
of the acute HAE attacks in the real life setting through a call center in France.
Methods
A pre-specified ancillary study of SOS-HAE, a cluster-randomized prospective multicenter
trial, was conducted. HAE patients were recruited from 8 participating reference centers.
The outcome of interest was the rate of hospitalization.
Results
onerhundred patients were included. The median (quartile) age was 38 (29–53) years,
and 66 (66%) were female. Eighty (80%) patients had HAE type I, 8 (8%) had HAE type
II and 12 (12%) patients had FXII-HAE. Fifty-one (51%) patients had experienced at
least one time the call center during the follow-up. Nine over 166 (5%) attacks for
9 different patients resulted in hospital admission to the hospital (in the short-stay
unit, ie, <24 h) during the follow-up period. During 2 years, there were 166 calls
to call center for 166 attacks. All attacks were treated at home after call center
contact.
Conclusions
Use of emergency departments and hospitalizations are reduced by the use of a coordinated
national call center in HAE after therapeutic education program that promoted self-administration
of specific treatment and use of call to call center.
Trial registration
clinicalTrials.gov identifier: NCT01679912
Keywords
Abbreviations:
C1-INH (C1-Inhibitor), ED (Emergency department), FXII-HAE (Factor XII-hereditary angiœdema), HAE (Hereditary angiœdema), IQR (Interquartile range), SD (Standard deviation)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 17, 2019
Accepted:
May 13,
2019
Received in revised form:
March 17,
2019
Received:
June 21,
2018
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
