Highlights
- •Hyperthyroidism could be a risk factor for VTE but data is quite limited.
- •This meta-analysis gathered all available data from 5 retrospective cohort studies.
- •A significantly increased risk of VTE among patients with hyperthyroidism is found.
- •The pooled risk ratio was 1.332 (95% CI, 1.275–1.391; I2 14%).
Abstract
Background
Studies have suggested that patients with hyperthyroidism may have a higher risk of
venous thromboembolism (VTE) compared to individuals with normal thyroid function,
although the data is quite limited. This systematic review and meta-analysis aims
to comprehensively investigate this risk by summarizing all available studies.
Methods
A systematic review was performed using the MEDLINE and Embase databases from inception
to February 2019 to identify all cohort studies that compared the risk of incident
VTE in patients with hyperthyroidism versus individuals without hyperthyroidism. Pooled
risk ratio and 95% confidence interval were calculated using random-effect, generic
inverse-variance method.
Results
A total of 5 retrospective cohort studies with 237,667 cases with hyperthyroidism
and 4,615,907 comparators without hyperthyroidism were included. The pooled analysis
found a significantly increased risk of incident VTE among patients with hyperthyroidism,
with a pooled risk ratio of 1.332 (95% CI, 1.275–1.391; I2 14%). The funnel plot was asymmetric and may suggest the presence of publication
bias in favor of studies that showed positive association.
Conclusion
A significantly increased risk of incident VTE among patients with hyperthyroidism
compared to individuals without hyperthyroidism was demonstrated in this meta-analysis.
Keywords
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Article info
Publication history
Published online: June 19, 2019
Received in revised form:
May 31,
2019
Received:
May 11,
2019
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
