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Clinical course of primary immune thrombocytopenia with positive antiphospholipid antibodies

  • Ana Clara Ladeira Cruz
    Affiliations
    School of Medical Sciences, University of Campinas, Brazil RuaTessália Vieira de Camargo, 126. Cidade Universitária "Zeferino Vaz", CEP: 13083-887 Campinas, SP, Brazil
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  • Marina Pereira Colella
    Affiliations
    Thrombosis and Haemostasis Unit, Hematology and Hemotherapy Center, University of Campinas, Rua Carlos Chagas, 480. Cidade Universitária "ZeferinoVaz", CEP: 13083-970 Campinas, SP, Brazil
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  • Erich Vinícius De Paula
    Affiliations
    Thrombosis and Haemostasis Unit, Hematology and Hemotherapy Center, University of Campinas, Rua Carlos Chagas, 480. Cidade Universitária "ZeferinoVaz", CEP: 13083-970 Campinas, SP, Brazil

    Discipline of Hematology and Hemotherapy, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Brazil RuaTessália Vieira de Camargo, 126. Cidade Universitária "Zeferino Vaz", CEP: 13083-887 Campinas, SP, Brazil
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  • Joyce Annichinno-Bizzachi
    Affiliations
    Thrombosis and Haemostasis Unit, Hematology and Hemotherapy Center, University of Campinas, Rua Carlos Chagas, 480. Cidade Universitária "ZeferinoVaz", CEP: 13083-970 Campinas, SP, Brazil

    Discipline of Hematology and Hemotherapy, Department of Internal Medicine, School of Medical Sciences, University of Campinas, Brazil RuaTessália Vieira de Camargo, 126. Cidade Universitária "Zeferino Vaz", CEP: 13083-887 Campinas, SP, Brazil
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  • Fernanda Andrade Orsi
    Correspondence
    Corresponding author at: Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Brazil Rua Tessália Vieira de Camargo, 126. Cidade Universitária "Zeferino Vaz", CEP: 13083-887 Campinas, SP, Brazil.
    Affiliations
    School of Medical Sciences, University of Campinas, Brazil RuaTessália Vieira de Camargo, 126. Cidade Universitária "Zeferino Vaz", CEP: 13083-887 Campinas, SP, Brazil

    Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Brazil Rua Tessália Vieira de Camargo, 126. Cidade Universitária "ZeferinoVaz", CEP: 13083-887 Campinas, SP, Brazil
    Search for articles by this author
Published:August 22, 2019DOI:https://doi.org/10.1016/j.ejim.2019.08.013
      Antiphospholipid antibodies (aPL) are frequently detected in immune thrombocytopenia (ITP) and whether they play a role in ITP prognosis is controversial. Previous studies have shown that aPL positivity may not be associated with either platelet counts or response to treatment [
      • Frison L.
      • Lombardi A.
      • Caputo I.
      • Semenzato G.
      • Fabris F.
      • Vianello F.
      Relevance of antiphospholipid antibody profile in the clinical outcome of ITP: a single-centre study.
      ,
      • Dayama A.
      • Dass J.
      • Mahapatra M.
      • Saxena R.
      Incidence of antiphospholipid antibodies in patients with immune thrombocytopenia and correlation with treatment with steroids in North Indian population.
      ,
      • Comellas-Kirkerup L.
      • Hernandez-Molina G.
      • Cabral A.R.
      Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to the Sapporo revised classification criteria: a 6-year follow-up study.
      ,
      • Pierrot-Deseilligny Despujol C.
      • Michel M.
      • Khellaf M.
      • Gouault M.
      • Intrator L.
      • Bierling P.
      • et al.
      Antiphospholipid antibodies in adults with immune thrombocytopenic purpura.
      ]; however, heterogeneity in the classification of ITP outcomes and high variability of aPL assays performed across studies may affect results consistency.

      Keywords

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