Benefits of statins in chronic obstructive pulmonary disease patients with pulmonary hypertension: A meta-analysis

Published:October 31, 2019DOI:


      • Statins significantly decreased SPAP in COPD-PH.
      • Statins significantly improved 6MWD in COPD-PH.
      • Statins was beneficial in the management of COPD-associated PH.



      This meta-analysis was performed to evaluate the efficacy of statins in chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH).


      A systematic search was made of MEDLINE, Cochrane, ISI Web of Science and SCOPUS databases. Randomized clinical trials on treatment of COPD-PH with the statins, compared with placebo, were reviewed. Studies were pooled to weighted mean differences (WMD), with 95% confidence interval (CI).


      Five trials (enrolling 270 participants) met the inclusion criteria.
      Compared with placebo, the statins presented significant effects on systolic pulmonary artery pressure (WMD -4.52 mmHg; 95% CI -6.32 to -2.72 mmHg) and 6-min walk distance (6MWD) (WMD 32.46 m; 95% CI 13.63–51.29 m).


      Statins therapy significantly improves PH and 6MWD in COPD patients with PH.

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