I read with great interest the paper by Zucchelli et al. [
[1]
], which is a cohort study to determine the effect of frailty on mortality in adults
aged 60+ without multi-morbidity. Within the first 5 years of follow-up, adjusted
hazard ratios (HRs) (95% confidence intervals [CIs]) of pre-frail and frail participants
for mortality were 2.08 (1.15–3.76) and 2.69 (1.22–5.97), respectively. In contrast,
the significance disappeared beyond 5 years, and frailty and pre-frailty were closely
related to relatively short-term mortality in older adults free from multi-morbidity.
I have some queries on their study.Keywords
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References
- Frailty predicts short-term survival even in older adults without multimorbidity.Eur J Intern Med. 2018; 56: 53-56
- Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK biobank participants.Lancet Public Health. 2018; 3: e323-e332
- Combined effects of cognitive impairment and pre-frailty on future frailty and death in older Mexican Americans.Aging Ment Health. 2019; 23: 1405-1412
- Frail phenotype and mortality prediction: a systematic review and meta-analysis of prospective cohort studies.Int J Nurs Stud. 2015; 52: 1362-1374
- Frailty status predicts all-cause and cause-specific mortality in community dwelling older adults.J Am Med Dir Assoc. 2019; https://doi.org/10.1016/j.jamda.2019.06.007
Article info
Publication history
Published online: October 09, 2019
Accepted:
September 14,
2019
Received in revised form:
September 13,
2019
Received:
August 21,
2019
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
