Prevalence and risk factors associated with fatal adverse drug reactions among patients admitted at a Spanish teaching hospital

Published:October 17, 2019DOI:


      • The prevalence of drug-related deaths was 0.74% of hospital admissions, and 0.47% in the case of hospital-acquired drugs.
      • The risk factors associated with drug-related deaths were age, admission at the intensive care unit, and length of stay.
      • The AUC ROC value was 0.82 showing a good predictive potential for the risk factors studied.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • European Commission
        Proposal for a regulation amending, as regards pharmacovigilance of medicinal products for human use. Regulation (EC) no 726/2004.
        in: Impact Assessment. 2008 ([Available from: 12_2008/pharmacovigilance-ia-vol1_en.pdf. Accessed 9 Aug 2019])
        • Bouvy J.C.
        • De Bruin M.L.
        • Koopmanschap M.A.
        Epidemiology of adverse drug reactions in Europe: a review of recent observational studies.
        Drug Saf. 2015; 38: 437-453
        • Pardo Cabello A.J.
        • Del Pozo Gavilán E.
        • Gómez Jiménez F.J.
        • Mota Rodríguez C.
        • Luna Del Castillo Jde D.
        • Puche Cañas E.
        Drug-related mortality among inpatients: a retrospective observational study.
        Eur J Clin Pharmacol. 2016; 72: 731-736
        • Peter J.V.
        • Varghese G.H.
        • Alexander H.
        • Tom N.R.
        • Swethalekshmi V.
        • Truman C.
        • et al.
        Patterns of adverse drug reaction in the medical wards of a teaching hospital: a prospective observational cohort study.
        Curr Drug Saf. 2016; 11: 164-171
        • Rodenburg E.M.
        • Stricker B.H.
        • Visser L.E.
        Sex-related differences in hospital admissions attributed to adverse drug reactions in the Netherlands.
        Br J Clin Pharmacol. 2011; 71: 95-104
        • Lisha J.
        • Annalakshmi V.
        • Maria J.
        • Padmini D.
        Adverse drug reactions in critical care settings: a systematic review.
        Curr Drug Saf. 2017; 12: 147-161
        • Holm L.
        • Ekman E.
        • Jorsäter Blomgren K.
        Influence of age, sex and seriousness on reporting of adverse drug reactions in Sweden.
        Pharmacoepidemiol Drug Saf. 2017; 26: 335-343