The metabolic syndrome (MtS) is present in the 25% of the population of Western countries
[
[1]
]. MtS is frequently associated with hyperferritinemia (HF) and this can be produced
by mutations in the HFE gene [
[2]
,
[3]
]. Mutations in the HFE gene, such as H63D / H63D, can be associated with MtS [
[2]
].To read this article in full you will need to make a payment
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References
- Prevalence of the metabolic syndrome in Luxembourg according to the Joint Interim Statement definition estimated from the Oriscav-Lux study.BMC Public Health. 2011; 11: 4
- Impact of H63D mutations, magnetic resonance and metabolic syndrome among outpatient referrals for elevated serum ferritin in the Basque Country.Ann Hepatol. 2015; 14: 333-339
- How should hyperferritinemia be investigated and managed?.Eur J Intern Med. 2016; 33: 21-27
- Diagnostic algorithm for high iron overload: results from a prospective study of 312 patients with hyperferritinemia.J Hepatol. 2016; 64: S296
- Harmonizing the metabolic syndrome. a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the study of obesity.Circulation. 2009; 120: 1640-1645
- HFE gene mutations analysis in Basque Country hereditary hemochromatosis patients and controls.Eur J Hum Genet. 2001; 9: 294-300
- Liver iron concentraion is not raised in patients with dysmetabolic hyperferritinemia.Ann Hepatol. 2016; 15: 540-544
- Gender and plasma iron biomarkers, but not HFE gene mutations, increase the risk of colorectal cancer and polyps.Tumour Biol. 2015; 36: 6959-6963
Article info
Publication history
Published online: November 30, 2019
Accepted:
November 26,
2019
Received in revised form:
November 23,
2019
Received:
September 22,
2019
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
