Tocilizumab (TCZ) is a humanized monoclonal antibody directed against the interleukin-6
(IL-6) receptor licensed for the treatment of rheumatoid arthritis, systemic juvenile
idiopathic arthritis and giant cell arteritis or used off label in other refractory
autoimmune diseases [
1
,
- Michaud M.
- Lidove O.
- Bienvenu B.
- Chiche L.
- Urbanski G.
TOCIMAI Investigators group
Effectiveness and tolerance of off-label use of tocilizumab in autoimmune diseases: a multicenter study.
Effectiveness and tolerance of off-label use of tocilizumab in autoimmune diseases: a multicenter study.
Joint Bone Spine. 2019; https://doi.org/10.1016/j.jbspin.2019.08.002
2
,
3
].Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Effectiveness and tolerance of off-label use of tocilizumab in autoimmune diseases: a multicenter study.Joint Bone Spine. 2019; https://doi.org/10.1016/j.jbspin.2019.08.002
- Biological treatments in giant cell arteritis & takayasu arteritis.Eur J Intern Med. 2018; 50: 12-19
Samson M., Devilliers H., Ly K.H., Maurier F., Bienvenu B., Terrier B. et al. Tocilizumab as an add-on therapy to glucocorticoids during the first 3 months of treatment of giant cell arteritis: a prospective study.Eur J Intern Med2018;57:96–104.
- Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions.Ann Rheum Dis. 2013; 72: 482-492
- Glucocorticoid dosages and acute‐phase reactant levels at giant cell arteritis flare in a randomized trial of tocilizumab.Arthritis Rheum. 2019; 71: 1329-1338
- Serum amyloid a concentrations in giant-cell arteritis and polymyalgia rheumatica: a useful test in the management of the disease.Clin Exp Rheumatol. 1991; 9: 157-163
Article info
Publication history
Published online: January 13, 2020
Accepted:
December 17,
2019
Received:
December 9,
2019
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
