Highlights
- •Systemic lupus erythematosus (SLE) is characterized by a systemic involvement.
- •SLE patients have an impaired myocardial function involving both ventricles.
- •A specific cardiovascular prevention strategy is needed in SLE patients.
- •Systemic lupus erythematosus patients have an impaired myocardial function involving both left and right ventricle.
- •Screening of cardiovascular risk factors and cardiovascular prevention strategy are needed in this clinical setting.
Abstract
Background
Systemic lupus erythematosus (SLE), is characterized by a systemic involvement including
myocardial dysfunction. Being standard echocardiography not able at fully detecting
subclinical alterations, speckle tracking echocardiography (STE) has recently emerged
as a quantitative ultrasound technique to accurately estimate myocardial function.
Methods
We conducted a systematic review with meta-analysis of studies reporting STE parameters
in patients with SLE.
Results
A total of 9 studies were included in the analysis. Left ventricle global longitudinal
strain (GLS) was significantly lower in SLE patients than in non-SLE controls (MD:
−2.331, 95% CI: −3.083, −1.580, p < 0.001). In addition, we found significant differences between SLE patients and
non-SLE controls in left ventricle GLS rate (MD: −0.115, 95% CI: −0.177 to 0.063,
p < 0.001), left ventricle circumferential strain(MD: −1.841, 95% CI: −3.160 to 0.521,
p = 0.006) and left ventricle radial strain(MD: −11.03, 95% CI: −13.819 to 8.241, p < 0.001). Right ventricle strain was significantly lower in SLE patients than in non-SLE
controls (MD: −5.814, 95% CI: −7.347, −4.281, p < 0.001). Meta-regression models showed a lower difference in left ventricle GLS between
SLE cases and controls for studies with a higher prevalence of female gender and higher
prevalence of hypertension.
Conclusions
SLE patients have lower STE parameters than controls, thus suggesting the presence
of an impaired myocardial function involving both left and right ventricle.
Keywords
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Article info
Publication history
Published online: January 05, 2020
Accepted:
December 30,
2019
Received in revised form:
December 17,
2019
Received:
November 3,
2019
Identification
Copyright
© 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
