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Speckle tracking echocardiography in patients with systemic lupus erythematosus: A meta-analysis

Published:January 05, 2020DOI:https://doi.org/10.1016/j.ejim.2019.12.033

      Highlights

      • Systemic lupus erythematosus (SLE) is characterized by a systemic involvement.
      • SLE patients have an impaired myocardial function involving both ventricles.
      • A specific cardiovascular prevention strategy is needed in SLE patients.
      • Systemic lupus erythematosus patients have an impaired myocardial function involving both left and right ventricle.
      • Screening of cardiovascular risk factors and cardiovascular prevention strategy are needed in this clinical setting.

      Abstract

      Background

      Systemic lupus erythematosus (SLE), is characterized by a systemic involvement including myocardial dysfunction. Being standard echocardiography not able at fully detecting subclinical alterations, speckle tracking echocardiography (STE) has recently emerged as a quantitative ultrasound technique to accurately estimate myocardial function.

      Methods

      We conducted a systematic review with meta-analysis of studies reporting STE parameters in patients with SLE.

      Results

      A total of 9 studies were included in the analysis. Left ventricle global longitudinal strain (GLS) was significantly lower in SLE patients than in non-SLE controls (MD: −2.331, 95% CI: −3.083, −1.580, p < 0.001). In addition, we found significant differences between SLE patients and non-SLE controls in left ventricle GLS rate (MD: −0.115, 95% CI: −0.177 to 0.063, p < 0.001), left ventricle circumferential strain(MD: −1.841, 95% CI: −3.160 to 0.521, p = 0.006) and left ventricle radial strain(MD: −11.03, 95% CI: −13.819 to 8.241, p < 0.001). Right ventricle strain was significantly lower in SLE patients than in non-SLE controls (MD: −5.814, 95% CI: −7.347, −4.281, p < 0.001). Meta-regression models showed a lower difference in left ventricle GLS between SLE cases and controls for studies with a higher prevalence of female gender and higher prevalence of hypertension.

      Conclusions

      SLE patients have lower STE parameters than controls, thus suggesting the presence of an impaired myocardial function involving both left and right ventricle.

      Keywords

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