Advertisement

Cardiac and vascular damage in systemic erythematosus lupus. Is disease activity the mediator?

  • Giacomo Pucci
    Correspondence
    Corresponding author at: Giacomo Pucci, Department of Medicine, University of Perugia, Unit of Internal Medicine, Terni University Hospital, Piazzale Tristano di Joannuccio, 1, IT-05100 Terni, Italy.
    Affiliations
    Department of Medicine, University of Perugia, Italy

    Unit of Internal Medicine, Terni University Hospital, Terni, Italy
    Search for articles by this author
  • Gaetano Vaudo
    Affiliations
    Department of Medicine, University of Perugia, Italy

    Unit of Internal Medicine, Terni University Hospital, Terni, Italy
    Search for articles by this author
Published:January 27, 2020DOI:https://doi.org/10.1016/j.ejim.2020.01.013
      Cardiovascular (CV) risk associated with Systemic Erythematosus Lupus (SLE) yet remains an issue of great interest and current debate. Results from a large number of epidemiological studies clearly indicate SLE as a clinical condition associated with an increased CV risk. Such risk is estimated to be as more than twofold higher than what predicted by traditional CV risk factors (CVRFs) such as age, sex, hypertension, diabetes mellitus, dyslipidemia, smoking, sedentary behavior and obesity [
      • Tektonidou MG
      • Wang Z
      • Ward MM
      Brief report: trends in hospitalizations due to acute coronary syndromes and stroke in patients with systemic lupus erythematosus, 1996 to 2012.
      ,
      • Arkema EV
      • Svenungsson E
      • Von Euler M
      • Sjöwall C
      • Simard JF
      Stroke in systemic lupus erythematosus: a Swedish population-based cohort study.
      ].
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Tektonidou MG
        • Wang Z
        • Ward MM
        Brief report: trends in hospitalizations due to acute coronary syndromes and stroke in patients with systemic lupus erythematosus, 1996 to 2012.
        Arthritis Rheumatol. 2016; 68: 2680-2685
        • Arkema EV
        • Svenungsson E
        • Von Euler M
        • Sjöwall C
        • Simard JF
        Stroke in systemic lupus erythematosus: a Swedish population-based cohort study.
        Ann Rheum Dis. 2017; 76: 1544-1549
        • Sinicato NA
        • da Silva Cardoso PA
        • Appenzeller S
        Risk factors in cardiovascular disease in systemic lupus erythematosus.
        Curr Cardiol Rev. 2013; 9: 15-19
        • Tao C.Y.
        • Shang J.
        • Chen T.
        • Yu D.
        • Jiang Y.M.
        • Liu D.
        • et al.
        Impact of antimalarial (AM) on serum lipids in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis.
        Medicine (Baltimore). 2019; 98: e15030
        • Fanouriakis A
        • Kostopoulou M
        • Alunno A
        • Aringer M
        • Bajema I
        • Boletis JN
        • Cervera R
        • Doria A
        • Gordon C
        • Govoni M
        • Houssiau F
        • Jayne D
        • Kouloumas M
        • Kuhn A
        • Larsen JL
        • Lerstrøm K
        • Moroni G
        • Mosca M
        • Schneider M
        • Smolen JS
        • Svenungsson E
        • Tesar V
        • Tincani A
        • Troldborg A
        • van Vollenhoven R
        • Wenzel J
        • Bertsias G
        • Boumpas DT
        2019 update of the EULAR recommendations for the management of systemic lupus erythematosus.
        Ann Rheum Dis. 2019; 78: 736-745
        • Schoenfeld SR
        • Kasturi S
        • Costenbader KH
        The epidemiology of atherosclerotic cardiovascular disease among patients with SLE: a systematic review.
        Semin Arthritis Rheum. 2013; 43: 77-95
        • Aviña-Zubieta JA
        • To F
        • Vostretsova K
        • De Vera M
        • Sayre EC
        • Esdaile J
        Risk of myocardial infarction and stroke in newly diagnosed systemic lupus erythematosus: a general population-based study.
        Arthritis Care Res (Hoboken). 2017; 69: 849-856
        • Baragetti A
        • Ramirez GA
        • Magnoni M
        • Garlaschelli K
        • Grigore L
        • Berteotti M
        • Scotti I
        • Bozzolo E
        • Berti A
        • Camici PG
        • Catapano AL
        • Manfredi AA
        • Ammirati E
        • Norata GD
        Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus.
        Nutr Metab Cardiovasc Dis. 2018; 28: 53-63
      1. Salvetti M, Painia A, Andreolia L, Stassaldia D, Aggiustia C, Bertacchinia F, Agabiti Rosei C, Piantonia S, Franceschini F, Tincania A, Muiesan ML. Cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls: Are there any differences? Eur J Intern Med (in press) - https://doi.org/10.1016/j.ejim.2019.12.001.

      Linked Article