Advertisement

Antibiotic treatment in patients that present with solely non-specific symptoms and positive serology at a Lyme centre

Published:February 16, 2020DOI:https://doi.org/10.1016/j.ejim.2020.01.027
      Lyme Borreliosis (LB) is a tick-borne disease caused by Borrelia burgdorferi sensu lato (s.l.). Patients present with several specific manifestations, of which an erythema migrans (EM) occurs most frequently. However, patients suspected for LB are also referred to Lyme centres with solely non-specific symptoms and positive Borrelia serology. The most common non-specific symptoms in patients referred to a Lyme centre are severe fatigue, sleep disturbances, and stiffness in neck and/or back [
      • Zomer T.P.
      • Barendregt J.N.M.
      • van Kooten B.
      • van Bemmel T.
      • Landman G.W.
      • van Hees B.C.
      • et al.
      Non-specific symptoms in adult patients referred to a lyme centre.
      ].

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Zomer T.P.
        • Barendregt J.N.M.
        • van Kooten B.
        • van Bemmel T.
        • Landman G.W.
        • van Hees B.C.
        • et al.
        Non-specific symptoms in adult patients referred to a lyme centre.
        Clin Microbiol Infect. 2019; https://doi.org/10.1016/j.cmi.2018.09.016
        • Dutch Quality Institute for Health Care (CBO)
        Dutch National Guideline for Lyme Disease.
        Utrecht, July 2013
        • Berende A.
        • ter Hofstede H.J.M.
        • Vos F.J.
        • van Middendorp H.
        • Vogelaar M.L.
        • Tromp M.
        • et al.
        Randomized trial of longer-term therapy for symptoms attributed to lyme disease.
        N Engl J Med. 2016; 374: 1209-1220https://doi.org/10.1056/NEJMoa1505425
        • Klempner M.S.
        • Hu L.T.
        • Evans J.
        • Schmid C.H.
        • Johnson G.M.
        • Trevino R.P.
        • et al.
        Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of lyme disease.
        N Engl J Med. 2001; 345: 85-92https://doi.org/10.1056/NEJM200107123450202
        • Krupp L.B.
        • Hyman L.G.
        • Grimson R.
        • Coyle P.K.
        • Melville P.
        • Ahnn S.
        • et al.
        Study and treatment of post lyme disease (STOP-LD): a randomized double masked clinical trial.
        Neurology. 2003; 60: 1923-1930https://doi.org/10.1212/01.WNL.0000071227.23769.9E
        • Worm-Smeitink M.
        • Gielissen M.
        • Bloot L.
        • van Laarhoven H.W.M.
        • van Engelen B.G.M.
        • van Riel P.
        • et al.
        The assessment of fatigue: psychometric qualities and norms for the checklist individual strength.
        J Psychosom Res. 2017; 98: 40-46https://doi.org/10.1016/j.jpsychores.2017.05.007
        • Beck A.T.
        • Steer R.A.
        • Brown G.K
        Manual for the beck depression inventory-II.
        Psychological Corporation, San Antonio, TX1996