Sudden death can be the initial presentation of pulmonary embolism and early fatality
is substantial among patients who present with haemodynamic instability [
[1]
,
[2]
]. Death from pulmonary embolism, namely with pulmonary embolism starting the chain of medical
events leading to death, remains a major contributor to cardiovascular mortality in
Europe [
[3]
] and the United States [
- Barco S.
- Mahmoudpour S.H.
- Valerio L.
- et al.
Trends in mortality related to pulmonary embolism in the European Region, 2000-15:
analysis of vital registration data from the WHO Mortality Database.
Lancet Respir Med. 2019; https://doi.org/10.1016/S2213-2600(19)30354-6
[4]
]. Raising general awareness, a broader implementation of available preventive and
diagnostic strategies, better criteria to identify higher risk patients, and safer
reperfusion regimens represent unmet needs to reduce global pulmonary embolism-related
mortality [
[2]
,
5
,
6
,
7
,
8
]. A clear definition of pulmonary embolism-related death will improve our ability
to interpret the results of epidemiological studies and put the utility of interventions
into the right perspective [
[9]
].To read this article in full you will need to make a payment
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References
- ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).Eur Heart J. 2020; 41: 543-603
- Pulmonary embolism.Nat Rev Dis Primers. 2018; 4: 18028
- Trends in mortality related to pulmonary embolism in the European Region, 2000-15: analysis of vital registration data from the WHO Mortality Database.Lancet Respir Med. 2019; https://doi.org/10.1016/S2213-2600(19)30354-6
- Global Burden of Thrombosis Epidemiologic Aspects.Circulation Research. 2016; 118: 1340-1347
- Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials.Eur Respir J. 2018; 51
- Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score.Thromb Haemost. 2016; 115: 827-834
- Fifty years of research on antithrombotic therapy: achievements and disappointments.Eur J Intern Med. 2019; 70: 1-7
- Optimizing the personalized, risk-adjusted management of pulmonary embolism: an integrated clinical trial programme.Hamostaseologie. 2019; 39: 117-127
- Definitions, adjudication, and reporting of pulmonary embolism-related death in clinical studies: a systematic review.J Thromb Haemost. 2019; 17: 1590-1607
- Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients.Thromb Haemost. 2005; 93: 76-79
- Mortality in patients with intracerebral hemorrhage associated with antiplatelet agents, oral anticoagulants or no antithrombotic therapy.Eur J Intern Med. 2020; https://doi.org/10.1016/j.ejim.2019.12.016
- Hypercoagulabilty, venous thromboembolism, and death in patients with cancer. A Multi-State Model.Thromb Haemost. 2016; 115: 817-826
- Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model.Eur Respir J. 2016; 48: 780-786
- Wells rule and d-dimer testing to rule out pulmonary embolism: a systematic review and individual-patient data meta-analysis.Ann Intern Med. 2016; 165: 253-261
- Short and long-term mortality in elderly patients with suspected not confirmed pulmonary embolism.Eur J Intern Med. 2019; https://doi.org/10.1016/j.ejim.2019.10.024
- Alternative diagnoses in patients in whom the GP considered the diagnosis of pulmonary embolism.Fam Pract. 2014; 31: 670-677
- Clinical impact of findings supporting an alternative diagnosis on CT pulmonary angiography in patients with suspected pulmonary embolism.Chest. 2013; 144: 1893-1899
- Finding an alternative diagnosis does not justify increased use of CT-pulmonary angiography.BMC Pulm Med. 2013; 13: 9
- Hyponatraemia during an emergency medical admission as a marker of illness severity & case complexity.Eur J Intern Med. 2019; 59: 60-64
- Admission glucose level was associated with increased short-term mortality and length-of-stay irrespective of diagnosis, treating medical specialty or concomitant laboratory values.Eur J Intern Med. 2020; https://doi.org/10.1016/j.ejim.2020.01.010
- Beyond the guidelines: Novelties, changes and unsolved issues from the 2019 ESC guidelines on pulmonary embolism.Eur J Intern Med. 2019; https://doi.org/10.1016/j.ejim.2019.11.001
- Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial.Eur Heart J. 2020; 41: 509-518
- Potentially avoidable 30-day hospital readmissions in medical patients: derivation and validation of a prediction model.JAMA Intern Med. 2013; 173: 632-638
Article info
Publication history
Published online: February 09, 2020
Accepted:
January 31,
2020
Received:
January 30,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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- Short and long-term mortality in elderly patients with suspected not confirmed pulmonary embolismEuropean Journal of Internal MedicineVol. 73
