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THE role of metabolic syndrome in blood pressure control and pulse wave velocity progression over a 3.5 years in treated hypertensive PATIENTS.

Published:February 18, 2020DOI:https://doi.org/10.1016/j.ejim.2020.02.005
      Metabolic Syndrome (MS) is a cluster of elevated Blood Pressure (BP) and glucose, lipids alterations (elevated triglycerides or low HDL-cholesterol) and abdominal obesity that has been associated with a significant increase in Cardio-Vascular (CV) events and mortality [
      • Khang Y.H.
      • Cho S.I.
      • Kim H.R.
      Risks for cardiovascular disease, stroke, ischaemic heart disease, and diabetes mellitus associated with the metabolic syndrome using the new harmonised definition: findings from nationally representative longitudinal data from an asian population.
      ]. It is highly prevalent in hypertensive patients [
      • Barrios V.
      • Escobar C.
      • Calderón A.
      • Llisterri J.L.
      • Alegría E.
      • Muñiz J.
      • Matalí A
      Prevalence of the metabolic syndrome in patients with hypertension treated in general practice in spain: an assessment of blood pressure and low-density lipoprotein cholesterol control and accuracy of diagnosis.
      ] but data on the longitudinal trends of BP values in hypertensives with and without MS are very limited [
      • Safar M.E.
      • Lange C.
      • Blacher J.
      • Eschwège E.
      • Tichet J.
      • Balkau B.
      • Study Group D.E.S.I.R.
      Mean and yearly changes in blood pressure with age in the metabolic syndrome: the desir study.
      ,
      • Xiao J.
      • Hua T.
      • Shen H.
      • Zhang M.
      • Wang X.J.
      • Gao Y.X.
      • Lu Q.
      • Wu C
      Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural china.
      ]. Furthermore, MS is characterized by an increase in Pulse Wave Velocity (PWV) but this relationship has been poorly evaluated in longitudinal studies.

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      References

        • Khang Y.H.
        • Cho S.I.
        • Kim H.R.
        Risks for cardiovascular disease, stroke, ischaemic heart disease, and diabetes mellitus associated with the metabolic syndrome using the new harmonised definition: findings from nationally representative longitudinal data from an asian population.
        Atherosclerosis. 2010; 213: 579-585
        • Barrios V.
        • Escobar C.
        • Calderón A.
        • Llisterri J.L.
        • Alegría E.
        • Muñiz J.
        • Matalí A
        Prevalence of the metabolic syndrome in patients with hypertension treated in general practice in spain: an assessment of blood pressure and low-density lipoprotein cholesterol control and accuracy of diagnosis.
        J Cardiometab Syndr. 2007; 2: 9-15
        • Safar M.E.
        • Lange C.
        • Blacher J.
        • Eschwège E.
        • Tichet J.
        • Balkau B.
        • Study Group D.E.S.I.R.
        Mean and yearly changes in blood pressure with age in the metabolic syndrome: the desir study.
        Hypertens Res. 2011; 34: 91-97
        • Xiao J.
        • Hua T.
        • Shen H.
        • Zhang M.
        • Wang X.J.
        • Gao Y.X.
        • Lu Q.
        • Wu C
        Associations of metabolic disorder factors with the risk of uncontrolled hypertension: a follow-up cohort in rural china.
        Sci Rep. 2017; 7: 743
        • Safar M.E.
        • Thomas F.
        • Blacher J.
        • et al.
        Metabolic syndrome and age-related progression of aortic stiffness.
        J Am Coll Cardiol. 2006; 47: 72-75
        • Tomiyama H.
        • Hirayama Y.
        • Hashimoto H.
        • Yambe M.
        • Yamada J.
        • Koji Y.
        • Motobe K.
        • Shiina K.
        • Yamamoto Y.
        • Yamashinai A
        The effects of changes in the metabolic syndrome detection status on arterial stiffening: a prospective study.
        Hypertens Res. 2006; 29: 673-678
        • Meani P.
        • Maloberti A.
        • Sormani P.
        • Colombo G.
        • Giupponi L.
        • Stucchi M.
        • Varrenti M.
        • Vallerio P.
        • Facchetti R.
        • Grassi G.
        • Mancia G.
        • Giannattasio C
        Determinants of carotid-femoral pulse wave velocity progression in hypertensive patients over a 3.7 years follow-up.
        Blood Press. 2018; 27: 32-40
        • Bruno R.M.
        • Cartoni G.
        • Stea F.
        • Armenia S.
        • Bianchini E.
        • Buralli S.
        • Giannarelli C.
        • Taddei S.
        • Ghiadoni L
        Carotid and aortic stiffness in essential hypertension and their relation with target organ damage: the catod study.
        J Hypertens. 2017; 35: 310-318
      1. The reference values for arterial stiffness’ collaboration. determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values.
        Eur. Heart J. 2010; 31: 2338-2350
        • Taddei S.
        • Virdis A.
        • Mattei P.
        • Natali A.
        • Ferrannini E.
        • Salvetti A.
        Effect of insulin on acetylcholine-induced vasodilation in normotensive subjects and patients with essential hypertension.
        Circulation. 1995; 92: 2911-2918
        • Nakamura Y.
        • Fujii S.
        • Hoshino J.
        • Saito Y.
        • Mizuno H.
        • Saito Y.
        • et al.
        Selective angiotensin receptor antagonisms with valsartan decreases arterial stiffness independently of blood pressure lowering in hypertensive patients.
        Hypertens Res. 2005; 28: 937-943
        • De Marco M.
        • de Simone G.
        • Izzo R.
        • Mancusi C.
        • Sforza A.
        • Giudice R.
        • Trimarco B.
        • De Luca N
        Classes of antihypertensive medications and blood pressure control in relation to metabolic risk factors.
        Hypertens. 2012; 30: 188-193