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Prognostic value of adiponectin in patients with stable coronary artery disease in the era of statins

Published:April 29, 2020DOI:https://doi.org/10.1016/j.ejim.2020.04.005
      Adiponectin is a circulating cytokine produced by the adipose tissue. Experimental data suggest that adiponectin exerts beneficial effects on insulin sensitivity, chronic low-grade inflammation, oxidative stress and atherosclerotic process [
      • Schnabel R
      • Messow CM
      • Lubos E
      • et al.
      Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study.
      ]. Paradoxically, the majority of studies that addressed the association of circulating adiponectin levels with cardiovascular (CV) or total mortality, have found a positive, rather than the expected negative, relationship between adiponectin and mortality [
      • Scarale MG
      • Fontana A
      • Trischitta V
      • et al.
      Circulating adiponectin levels are paradoxically associated with mortality rate: a systematic review and meta-analysis.
      ].

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