Adiponectin is a circulating cytokine produced by the adipose tissue. Experimental
data suggest that adiponectin exerts beneficial effects on insulin sensitivity, chronic
low-grade inflammation, oxidative stress and atherosclerotic process [
[1]
]. Paradoxically, the majority of studies that addressed the association of circulating
adiponectin levels with cardiovascular (CV) or total mortality, have found a positive,
rather than the expected negative, relationship between adiponectin and mortality
[
[2]
].Keywords
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References
- Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study.Eur Heart J. 2008; 29: 649-657
- Circulating adiponectin levels are paradoxically associated with mortality rate: a systematic review and meta-analysis.J Clin Endocrinol Metab. 2019; 104: 1357-1368
- Adiponectin levels and risk of coronary heart disease: a meta-analysis of prospective studies.Am J Med Sci. 2013; 345: 455-461
- Adiponectin is associated with increased mortality and heart failure in patients with stable ischemic heart disease: data from the Heart and Soul study.Atherosclerosis. 2012; 220: 587-592
- Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain.Eur Heart J. 2006; 27: 2300-2309
- Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease.Eur Heart J. 2008; 29: 1307-1315
- Plasma adiponectin levels in relation to prognosis in patients with angiographic coronary artery disease.Metabolism. 2012; 61: 1803-1808
- Lipoprotein-associated phospholipase A2 (Lp-PLA2) bound on high density lipoprotein is associated with lower risk of cardiac death in stable coronary artery disease patients: a three year follow-up.J Am Coll Cardiol. 2012; 60: 2053-2060
- Lipid and blood pressure meta-analysis collaboration (LBPMC) group. Impact of statin therapy on plasma adiponectin concentrations: a systematic review and meta-analysis of 43 randomized controlled trial arms.Atherosclerosis. 2016; 253: 194-208
- Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts.Biol Cell. 2009; 101: 263-272
Article info
Publication history
Published online: April 29, 2020
Accepted:
April 3,
2020
Received:
March 1,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
