Highlights
- •P value has been criticized for being a source of misinterpretation and deception.
- •New approaches have been advanced to improve reproducibility of scientific researches.
- •Lowering p value threshold was proposed to reduce rate of false positives.
- •The proposal to lower p threshold has unknown impact on evidence based medicine.
- •Lowering p value threshold to 0.005 has a modest impact on current ESC STEMI guideline.
Keywords
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References
- The ASA's Statement on p-Values: Context, Process, and Purpose.The American Statistician. 2016; 70: 129-133
- Basic Appl Soc Psychol. 2015; 37 (editorial in): 1-2
- Why the P-value culture is bad and confidence intervals a better alternative.Osteoarth Cartil. 2012; 20 (Epub 2012 Apr 11. PubMed PMID:22503814): 805-808https://doi.org/10.1016/j.joca.2012.04.001
- The reign of the p-value is over: what alternative analyses could we employ to fill the power vacuum?.Biol Lett. 2019 May 31; 15 (PubMed PMID: 31113309; PubMed Central PMCID: PMC6548726)20190174https://doi.org/10.1098/rsbl.2019.0174
- Publishing research with P-values: Prescribe more stringent statistical significance or proscribe statistical significance?.Eur Heart J. 2019 Aug 14; 40: 2553-2554
- Options for publishing research without any P-values.Eur Heart J. 2019 Aug 14; 40: 2555-2556
- Redefine statistical significance.Nat Hum Behav. 2018; 2: 6-10
- The Proposal to Lower P Value Thresholds to .005.JAMA. 2018 Apr 10; 319: 1429-1430
- 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).Eur Heart J. 2018 Jan 7; 39: 119-177
- GreenlandS, SennSJ, RothmanKJ, CarlinJB, PooleC, GoodmanSN, AltmanDG. Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations Eur J Epidemiol. 2016 Apr;31(4):337-50.
Article info
Publication history
Published online: June 04, 2020
Accepted:
May 23,
2020
Received in revised form:
May 13,
2020
Received:
April 29,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.