Recently, we described in this Journal a simplified, yet accurate clinical decision
model (the RISE UP score) to predict 30-day mortality in older patients who visit
an emergency department [
[1]
]. Although several studies have shown that certain biomarkers are good predictors
of outcome as well, it remains enigmatic whether these have any additional value over
and above clinical decision rules such as ours. This is particularly true for the
elderly population. As part of the RISE UP study, we also collected blood for determination
of several biomarkers from the patients who participated in this study. This allowed
us to hypothesize that the already high discriminatory value of our clinical model
might improve even further when these biomarkers would be added to the score. The
markers that we tested were arterial lactate, hs-cTnT, NT-proBNP, D-dimer and procalcitonin
(PCT).- Zelis N.
- Buijs J.
- de Leeuw P.W.
- van Kuijk S.M.J.
- Stassen P.M.
A new simplified model for predicting 30-day mortality in older medical emergency
department patients: the rise up score.
Eur J Intern Med. 2020; https://doi.org/10.1016/j.ejim.2020.02.021
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References
- A new simplified model for predicting 30-day mortality in older medical emergency department patients: the rise up score.Eur J Intern Med. 2020; https://doi.org/10.1016/j.ejim.2020.02.021
- Study protocol for a multicentre prospective cohort study to identify predictors of adverse outcome in older medical emergency department patients (the Risk Stratification in the Emergency Department in Acutely Ill Older Patients (RISE UP) study).BMC Geriatr. 2019; 19: 65
- Risk stratification using d-dimers in patients presenting to the emergency department with nonspecific complaints.Eur J Intern Med. 2016; 31: 20-24
- Evaluation of the Mortality in Emergency Department Sepsis score combined with procalcitonin in septic patients.Am J Emerg Med. 2013; 31: 1086-1091
- Interpreting incremental value of markers added to risk prediction models.Am J Epidemiol. 2012; 176: 473-481
Article info
Publication history
Published online: July 25, 2020
Accepted:
July 19,
2020
Received in revised form:
July 7,
2020
Received:
June 30,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
