Advertisement

Relevance and diagnosis of disseminated intravascular coagulation associated with cardiovascular disease

Published:August 04, 2020DOI:https://doi.org/10.1016/j.ejim.2020.07.021
      Disseminated intravascular coagulation (DIC) is a complication of a myriad of disorders that are all associated with a systemic inflammatory response. DIC is considered as an important pathogenetic pathway contributing to organ dysfunction, for example in sepsis, severe trauma or other conditions [
      • Levi M.
      • Scully M.
      How I treat disseminated intravascular coagulation.
      ]. Any form of systemic inflammation will often be associated with activation of coagulation, ranging from changes in molecular markers in coagulation factors with equivocal clinical significance to its most full-blown variant, which is DIC [
      • Gando S.
      • Levi M.
      • Toh C.H
      Disseminated intravascular coagulation.
      ].
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Levi M.
        • Scully M.
        How I treat disseminated intravascular coagulation.
        Blood. 2018; 131: 845-854
        • Gando S.
        • Levi M.
        • Toh C.H
        Disseminated intravascular coagulation.
        Nat Rev Dis. 2016; 2: 16037
        • Taylor F.B.
        • Jr Toh CH
        • Hoots W.K.
        • Wada H.
        • Levi M
        Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.
        Thromb Haemost. 2001; 86: 1327-1330
        • Bakhtiari K.
        • Meijers J.C.
        • de Jonge E.
        • Levi M
        Prospective validation of the international society of thrombosis and maemostasis scoring system for disseminated intravascular coagulation.
        Crit Care Med. 2004; 32: 2416-2421
        • Toh C.H.
        • Hoots W.K.
        The scoring system of the scientific and standardisation committee on disseminated intravascular coagulation of the international society on thrombosis and haemostasis: a five year overview.
        J Thromb Haemost. 2007; 5: 604-606
        • Dempfle C.E.
        • Wurst M.
        • Smolinski M.
        • Lorenz S.
        • Osika A.
        • Olenik D.
        • et al.
        Use of soluble fibrin antigen instead of d-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score.
        Thromb Haemost. 2004; 91: 812-818
        • Levi M.
        Pathogenesis and diagnosis of disseminated intravascular coagulation.
        Int J Lab Hematol. 2018; 40: 15-20
        • Iba T.
        • Levy J.H.
        • Thachil J.
        • Wada H.
        • Levi M
        The progression from coagulopathy to disseminated intravascular coagulation in representative underlying diseases.
        Thromb Res. 2019; 179: 11-14
        • Levi M.
        • Thachil J.
        • Iba T.
        • Levy J.H
        Coagulation abnormalities and thrombosis in patients with COVID-19.
        Lancet Haematol. 2020; 7: e438-ee40
        • Levi M.
        • Thachil J.
        Coronavirus disease 2019 coagulopathy: disseminated intravascular coagulation and thrombotic microangiopathy-either, neither, or both.
        Semin Thromb Hemost. 2020; https://doi.org/10.1055/s-0040-1712156
        • Levi M.
        Disseminated intravascular coagulation in cancer: an update.
        Semin Thromb Hemost. 2019; 45: 342-347
        • Levi M.
        Pathogenesis and management of peripartum coagulopathic calamities (disseminated intravascular coagulation and amniotic fluid embolism).
        Thromb Res. 2013; 131: S32-S34
        • Grafeneder J.
        • Krychtiuk K.A.
        • Buchtele N.
        • Schoergenhofer C.
        • Gelbenegger G.
        • Lenz M.
        • et al.
        The ISTH DIC score predicts outcome in non-septic patients admitted to a cvardiovascular intensive care unit.
        Eur J Int Med. 2020; https://doi.org/10.1016/j.ejim.2020.06.017
        • Dhainaut J.F.
        • Yan S.B.
        • Joyce D.E.
        • Pettila V.
        • Basson B.R.
        • Brandt J.T.
        • et al.
        Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation.
        J Thromb Haemost. 2004; 2: 1924-1933
        • Levi M.
        • Vincent J.L.
        • Tanaka K.
        • Radford A.H.
        • Kayanoki T.
        • Fineberg D.A.
        • et al.
        Effect of a recombinant human soluble thrombomodulin on baseline coagulation biomarker levels and mortality outcome in patients with sepsis-associated coagulopathy.
        Crit Care Med. 2020; 48: 1140-1147
        • Kinasewitz G.T.
        • Zein J.G.
        • Lee G.L.
        • Nazir S.A.
        • Taylor Jr., F.B.
        Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis.
        Crit Care Med. 2005; 33: 2214-2221
        • Dhainaut J.F.
        • Shorr A.F.
        • Macias W.L.
        • Kollef M.J.
        • Levi M.
        • Reinhart K.
        • et al.
        Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure.
        Crit Care Med. 2005; 33: 341-348