Disseminated intravascular coagulation (DIC) is a complication of a myriad of disorders
that are all associated with a systemic inflammatory response. DIC is considered as
an important pathogenetic pathway contributing to organ dysfunction, for example in
sepsis, severe trauma or other conditions [
[1]
]. Any form of systemic inflammation will often be associated with activation of coagulation,
ranging from changes in molecular markers in coagulation factors with equivocal clinical
significance to its most full-blown variant, which is DIC [
[2]
].To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- How I treat disseminated intravascular coagulation.Blood. 2018; 131: 845-854
- Disseminated intravascular coagulation.Nat Rev Dis. 2016; 2: 16037
- Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation.Thromb Haemost. 2001; 86: 1327-1330
- Prospective validation of the international society of thrombosis and maemostasis scoring system for disseminated intravascular coagulation.Crit Care Med. 2004; 32: 2416-2421
- The scoring system of the scientific and standardisation committee on disseminated intravascular coagulation of the international society on thrombosis and haemostasis: a five year overview.J Thromb Haemost. 2007; 5: 604-606
- Use of soluble fibrin antigen instead of d-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score.Thromb Haemost. 2004; 91: 812-818
- Pathogenesis and diagnosis of disseminated intravascular coagulation.Int J Lab Hematol. 2018; 40: 15-20
- The progression from coagulopathy to disseminated intravascular coagulation in representative underlying diseases.Thromb Res. 2019; 179: 11-14
- Coagulation abnormalities and thrombosis in patients with COVID-19.Lancet Haematol. 2020; 7: e438-ee40
- Coronavirus disease 2019 coagulopathy: disseminated intravascular coagulation and thrombotic microangiopathy-either, neither, or both.Semin Thromb Hemost. 2020; https://doi.org/10.1055/s-0040-1712156
- Disseminated intravascular coagulation in cancer: an update.Semin Thromb Hemost. 2019; 45: 342-347
- Pathogenesis and management of peripartum coagulopathic calamities (disseminated intravascular coagulation and amniotic fluid embolism).Thromb Res. 2013; 131: S32-S34
- The ISTH DIC score predicts outcome in non-septic patients admitted to a cvardiovascular intensive care unit.Eur J Int Med. 2020; https://doi.org/10.1016/j.ejim.2020.06.017
- Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation.J Thromb Haemost. 2004; 2: 1924-1933
- Effect of a recombinant human soluble thrombomodulin on baseline coagulation biomarker levels and mortality outcome in patients with sepsis-associated coagulopathy.Crit Care Med. 2020; 48: 1140-1147
- Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis.Crit Care Med. 2005; 33: 2214-2221
- Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure.Crit Care Med. 2005; 33: 341-348
Article info
Publication history
Published online: August 04, 2020
Accepted:
July 31,
2020
Received:
July 28,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.