Ulcerative colitis (UC) is characterized by an involvement of the large bowel which
leads to chronic systemic inflammation, increased aortic stiffness and reflected waves
[
1
,
2
,
3
,
4
] and an excess of cardiovascular events [
[5]
]. A recent expert panel statement suggests that aortic stiffness is an extraintestinal
manifestation of UC caused by chronic inflammation [
[6]
]. In this regard, the arterial phenotype of patients with UC is characterized by an
increase of both muscular and elastic artery stiffness [
[7]
]. A similar arterial phenotype has been described in other groups of patients with
chronic inflammation [
[8]
]. Interestingly, aortic pulse wave velocity (aPWV), a well-validated measure of aortic
stiffness, is reduced by anti-tumour necrosis factor therapy in patients with UC [
[9]
], suggesting that the reduction of inflammation is of benefit to the arterial wall
in these patients. Moreover, this therapy seems to be more effective in patients with
a recent diagnosis of UC [
[10]
]. Here we tested the hypothesis that bowel resection, a definitive therapy of ulcerative
colitis, reduces aPWV in these patients.Keywords
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References
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- Augmentation index is increased in patients with inflammatory bowel disease, a meta-analysis.Eur J Intern Med. 2017; 39: e31-e32
- risk of cerebrovascular accidents and ischemic heart disease in patients with inflammatory bowel disease: a systematic review and meta-analysis.Clin Gastroenterol Hepatol. 2014; 12: 382-393
- Aortic stiffening is an extraintestinal manifestation of inflammatory bowel disease: review of the literature and expert panel statement.Angiology. 2020; (E-pub ahead of print])
- Pulse wave velocity differs between ulcerative colitis and chronic kidney disease.Eur J Intern Med. Jan 2018; 47: 36-42
- Vascular consequences of inflammation: a position statement from the ESH working group on vascular structure and function and the ARTERY society.J Hypertens. 2020; ([E-pub ahead of print])
- Inflammation and aortic pulse wave velocity: a multicenter longitudinal study in patients with inflammatory bowel disease.J Am Heart Assoc. 2019; 8e010942
- Aortic stiffness in patients with inflammatory bowel disease reduced after anti-tumor necrosis factor therapy.J Am Coll Cardiol. 2019; 73: 981-982
Article info
Publication history
Published online: August 05, 2020
Accepted:
August 1,
2020
Received:
July 29,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
