Healthy and non healthy obese patients. The truth lies in the adipose tissue

Published:August 19, 2020DOI:


      • Cardioprotective omentin-1 was higher in obese patients without metabolic syndrome
      • Non-cardioprotective visfatin and resistin were lower in metabolically healthy obese patients
      • Adipose tissue might be involved in cardiovascular risk profile of obesity


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        • Smith GI
        • Mittendorfer B
        • Klein S
        Metabolically healthy obesity: facts and fantasies.
        J Clin Invest. 2019; 129: 3978-3989
        • Ryoo JH
        • Park SK
        • Ye S
        • et al.
        Estimation of risk for diabetes according to the metabolically healthy status stratified by degree of obesity in Korean men.
        Endocrine. 2015; 50: 650-658
        • Velho S
        • Paccaud F
        • Waeber G
        • et al.
        Metabolically healthy obesity: different prevalences using different criteria.
        Eur J Clin Nutr. 2010; 64: 1043-1051
        • Caleyachetty R
        • Thomas GN
        • Toulis KA
        • et al.
        Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women.
        J Am Coll Cardiol. 2017; 70: 1429-1437
        • Moussa O
        • Arhi C
        • Ziprin P
        • et al.
        Fate of the metabolically healthy obese-is this term a misnomer? A study from the Clinical Practice Research Datalink.
        Int J Obes (Lond). 2019; 43: 1093-1101
        • Smekal A
        • Vaclavik J
        Adipokines and cardiovascular disease: A comprehensive review.
        Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017; 161: 31-40
        • Alberti KG
        • Eckel RH
        • Grundy SM
        • et al.
        Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity.
        Circulation. 2009; 120: 1640-1645
        • Alizadeh S
        • Mirzaei K
        • Mohammadi C
        • et al.
        Circulating omentin-1 might be associated with metabolic health status in different phenotypes of body size.
        Arch Endocrinol Metab. 2017; 61: 567-574
        • Romacho T
        • Sanchez-Ferrer CF
        • Peiro C
        Visfatin/Nampt: an adipokine with cardiovascular impact.
        Mediators Inflamm. 2013; 2013946427
        • Bik W
        • Ostrowski J
        • Baranowska-Bik A
        • et al.
        Adipokines and genetic factors in overweight or obese but metabolically healthy Polish women.
        Neuro Endocrinol Lett. 2010; 31: 497-506
        • Ctoi AF
        • Parvu AE
        • Andreicut AD
        • et al.
        Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic Inflammation, Nitro-Oxidative Stress, and Insulin Resistance.
        Nutrients. 2018; : 10
        • Phillips CM
        • Perry IJ.
        Does inflammation determine metabolic health status in obese and nonobese adults?.
        J Clin Endocrinol Metab. 2013; 98: E1610-E1619