Dysnatremia is the most common electrolyte disorder in hospitalized patients [1].
Dysnatremia is generally classified as hyponatremia (<135mmol/L) and hypernatremia
(>145mmol/L). Many studies showed that hypernatremia and hyponatremia are independently
associated with an increased risk of poor clinical outcomes in hospitalized patients [1,
2], while serum sodium levels between 135 mmol/L and 145 mmol/L are previously treated
as normal. Recent studies have focused on the correlation between hospital mortality
and sodium fluctuations, even within sodium reference ranges [3]. Sodium fluctuation
could be a better parameter to indicate death. To our knowledge, no data were available
on the accuracy and optimal cut-off point to predict hospital mortality with sodium
fluctuations. We aim to explore the extent to which the sodium fluctuation during
hospitalization are associated with the risk of hospital mortality and to study the
value of predicting prognosis with sodium fluctuation.
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References
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Centre for Clinical Practice at N. National Institute for Health and Clinical Excellence: Guidance. Acutely Ill Patients in Hospital: Recognition of and Response to Acute Illness in Adults in Hospital. National Institute for Health and Clinical Excellence: Guidance. London: National Institute for Health and Clinical Excellence.; 2007.
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Article info
Publication history
Published online: November 19, 2020
Accepted:
November 11,
2020
Received:
October 26,
2020
Identification
Copyright
© 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
