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Comparative analysis of adropin concentration changes in response to kidney transplantation

Published:December 16, 2020DOI:https://doi.org/10.1016/j.ejim.2020.11.012
      Adropin acts as an energy regulator through lipid and glucose metabolism [
      • Brnić D.
      • Martinovic D.
      • Zivkovic P.M.
      • et al.
      Serum adropin levels are reduced in patients with inflammatory bowel diseases.
      ,
      • Kumar K.G.
      • et al.
      Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
      ]. This 76 amino acid protein encoded by the ENHO (Energy Homeostasis Associated Gene) gene is primarily expressed in the liver and the central nervous system. Therefore, adropin was also detected in muscle, heart, pancreas, and kidneys [
      • Brnić D.
      • Martinovic D.
      • Zivkovic P.M.
      • et al.
      Serum adropin levels are reduced in patients with inflammatory bowel diseases.
      ,
      • Kumar K.G.
      • et al.
      Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
      ]. Adropin is associated with carbohydrate-lipid metabolism, metabolic diseases [
      • Kumar K.G.
      • et al.
      Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.
      ,
      • Gao S.
      • McMillan R.P.
      • Zhu Q.
      • Lopaschuk G.D.
      • Hulver M.W.
      • Butler A.A.
      Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance.
      ,
      • Aydin S.
      • Kuloglu T.
      • Aydin S.
      • Kalayci M.
      • Yilmaz M.
      • Ҫakmak T.
      • et al.
      Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.
      ,
      • Yildirim B.
      • Celik O.
      • Aydin S.
      Adropin: a key component and potential gatekeeper of metabolic disturbances in policystic ovarian syndrome.
      ], endothelial function [
      • Zhang C.
      • Zhao L.
      • Xu W.
      • Li J.
      • Wang B.
      • Gu X.
      Correlation of serum adropin level with coronary artery disease.
      ] and cardiovascular disease [
      • Gao S.
      • McMillan R.P.
      • Zhu Q.
      • Lopaschuk G.D.
      • Hulver M.W.
      • Butler A.A.
      Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance.
      ,
      • Aydin S.
      • Kuloglu T.
      • Aydin S.
      • Kalayci M.
      • Yilmaz M.
      • Ҫakmak T.
      • et al.
      Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.
      ,
      • Yildirim B.
      • Celik O.
      • Aydin S.
      Adropin: a key component and potential gatekeeper of metabolic disturbances in policystic ovarian syndrome.
      ,
      • Zhang C.
      • Zhao L.
      • Xu W.
      • Li J.
      • Wang B.
      • Gu X.
      Correlation of serum adropin level with coronary artery disease.
      ,
      • Jasaszwili M.
      • Billert M.
      • Strowski M.Z.
      • Nowak K.W.
      • Skrzypski M.
      Adropin as a fat-burning hormone with multiple functions-review of a decade of research.
      ]. Additionally, Aydin et al. reported that adropin is produced locally in the glomerulus, peritubular interstitial cells, and peritubular capillary endothelial cells of the rat kidneys [
      • Aydin S.
      • Kuloglu T.
      • Aydin S.
      • Kalayci M.
      • Yilmaz M.
      • Ҫakmak T.
      • et al.
      Elevated adropin: a candidate diagnostic marker for myocardial infarction in conjunction with troponin-I.
      ].

      Keywords

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